87533-49-1Relevant academic research and scientific papers
Linker-Region Modified Derivatives of the Deoxyhypusine Synthase Inhibitor CNI-1493 Suppress HIV-1 Replication
Schr?der, Marcus,Kolodzik, Adrian,Windshügel, Bj?rn,Krepstakies, Marcel,Priyadarshini, Poornima,Hartjen, Philip,Van Lunzen, Jan,Rarey, Matthias,Hauber, Joachim,Meier, Chris
, p. 91 - 103 (2016/02/09)
The inhibition of cellular factors that are involved in viral replication may be an important alternative to the commonly used strategy of targeting viral enzymes. The guanylhydrazone CNI-1493, a potent inhibitor of the deoxyhypusine synthase (DHS), preve
Pyrimidinium-guanidiniminoethylphenyl-guanidinoalkyl-amines and guanidiniminoethylphenyl-guanidinoalkylamines as pharmaceutically active new substances
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Page/Page column 12; 21, (2008/06/13)
The present invention relates to new compositions and methods for use as pharmaceutically active agents, especially for prophylaxis and prevention in virally caused infections and diseases, tumor necrosis factor alpha (TNFα)-related inflammatory conditions and diseases, graft rejection after organ or tissue transplantations, and cancer. The innovative compounds are inhibitors of Hypusine formation and nuclear transport of distinct RNAs from nucleus to cytoplasm.
Trypanocidal 1,3-Arylene Diketone Bis(guanylhydrazone)s. Structure-Activity Relationships among Substituted and Heterocyclic Analogues
Ulrich, Peter,Cerami, Anthony
, p. 35 - 40 (2007/10/02)
Based on the antitrypanosomal activity of 1,3-diacetylbenzene bis(guanylhydrazone) (4) and 2,6-diacetylpyridine bis(guanylhydrazone (17), a number of substituted and heterocyclic 1,3-arylene diketone bis(guanylhydrazone)s were prepared and tested against
