875443-89-3Relevant academic research and scientific papers
Discovery of substituted biphenyl oxazolidinone inhibitors of cholesteryl ester transfer protein
Thompson, Christopher F.,Ali, Amjad,Quraishi, Nazia,Lu, Zhijian,Hammond, Milton L.,Sinclair, Peter J.,Anderson, Matt S.,Eveland, Suzanne S.,Guo, Qiu,Hyland, Sheryl A.,Milot, Denise P.,Sparrow, Carl P.,Wright, Samuel D.
supporting information; experimental part, p. 424 - 427 (2011/08/06)
Recently, there has been a strong interest in the ability to increase levels of high density lipoprotein-cholesterol (HDL-C). This interest stems from the hypothesis that such an elevation in HDL-C will decrease the likelihood of cardiovascular disease. I
CETP INHIBITORS
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Page/Page column 41-42, (2010/10/19)
Compounds having the structures of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors, and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis: In the compounds of Formula I, B or R2 is a phenyl group which has an ortho aryl, heterocyclic, benzoheterocyclic or benzocycloalky substituent, and one other position on the 5-membered ring has an aromatic, heterocyclic, cycloalkyl, benzoheterocyclic or benzocycloalky substituent connected directly to the ring or attached to the ring through a -CH2-.
