875478-11-8

Basic information

• Product Name: (S)-2-amino-3-phenyl-N-(prop-2-ynyl)propanamide
• Synonyms: (S)-2-amino-3-phenyl-N-(prop-2-ynyl)propanamide
• CAS NO: 875478-11-8
• Molecular Weight: 202.256
• Mol File: 875478-11-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (S)-2-amino-3-phenyl-N-(prop-2-ynyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-amino-3-phenyl-N-(prop-2-ynyl)propanamide(875478-11-8)
• EPA Substance Registry System: (S)-2-amino-3-phenyl-N-(prop-2-ynyl)propanamide(875478-11-8)

Safety Data

• Hazardous Substances Data: 875478-11-8(Hazardous Substances Data)

Upstream product

• 35661-40-6 N-Fmoc L-Phe 
• 461638-99-3 (S)-tert-butyl (1-oxo-3-phenyl-1-(prop-2-yn-1-ylamino)propan-2-yl)carbamate 
• 63-91-2 L-phenylalanine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 867335-87-3 4-[(2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3-phenylpropanamido]-1-propyne 

Downstream Products

• 867335-88-4 (R)-2-Azido-4-methyl-pentanoic acid ((S)-2-phenyl-1-prop-2-ynylcarbamoyl-ethyl)-amide 
• 1268671-17-5 L-phenylalanine-N-[(1-β-cyclodextrinyl-1H-1,2,3-triazol-4-yl)methylamide] 
• 1268672-11-2 C₁₅H₁₄N₂O₂ 
• 1449248-82-1 (S)-3-phenyl-2-(phenylamino)-N-(prop-2-ynyl)propanamide 
• 1608889-97-9 C₂₃H₂₇N₅O₃ 
• 1062578-14-6 (S)-5-benzyl-2,2-dimethyl-3-(prop-2-yn-1-yl)imidazolidin-4-one 
• 1358017-45-4 (S)-N-(1-oxo-3-phenyl-1-(prop-2-yn-1-ylamino)propan-2-yl)acrylamide 
• 890139-90-9 2-((R)-1-Azidomethyl-2-phenyl-ethylcarbamoyl)-5-{(R)-3-[3-((S)-2-phenyl-1-prop-2-ynylcarbamoyl-ethyl)-ureido]-4-triisopropylsilanyloxy-butyl}-furan-3,4-dicarboxylic acid dimethyl ester 
• 890139-92-1 2-((S)-1-Azidomethyl-2-phenyl-ethylcarbamoyl)-5-{(R)-3-[3-((S)-2-phenyl-1-prop-2-ynylcarbamoyl-ethyl)-ureido]-4-triisopropylsilanyloxy-butyl}-furan-3,4-dicarboxylic acid dimethyl ester 
• 890139-60-3 2-allyl 3,4-dimethyl 5-((R)-3-(3-((S)-1-oxo-3-phenyl-1-(prop-2-ynylamino)propan-2-yl)ureido)-4-(triisopropylsilyloxy)butyl)furan-2,3,4-tricarboxylate 

Relevant articles and documents

β-Sheet to Helical-Sheet Evolution Induced by Topochemical Polymerization: Cross-α-Amyloid-like Packing in a Pseudoprotein with Gly-Phe-Gly Repeats

Protein-mimics are of great interest for their structure, stability, and properties. We are interested in the synthesis of protein-mimics containing triazole linkages as peptide-bond surrogate by topochemical azide-alkyne cycloaddition (TAAC) polymerization of azide- and alkyne-modified peptides. The rationally designed dipeptide N3-CH2CO-Phe-NHCH2CCH (1) crystallized in a parallel β-sheet arrangement and are head-to-tail aligned in a direction perpendicular to the β-sheet-direction. Upon heating, crystals of 1 underwent single-crystal-to-single-crystal polymerization forming a triazole-linked pseudoprotein with Gly-Phe-Gly repeats. During TAAC polymerization, the pseudoprotein evolved as helical chains. These helical chains are laterally assembled by backbone hydrogen bonding in a direction perpendicular to the helical axis to form helical sheets. This interesting helical-sheet orientation in the crystal resembles the cross-α-amyloids, where α-helices are arranged laterally as sheets.

Chemical probes for competitive profiling of the quorum sensing signal synthase PqsD of Pseudomonas aeruginosa

The human pathogen Pseudomonas aeruginosa uses the pqs quorum sensing system to coordinate the production of its broad spectrum of virulence factors to facilitate colonization and infection of its host. Hereby, the enzyme PqsD is a virulence related quoru

Using click chemistry to access mono- and ditopic β-cyclodextrin hosts substituted by chiral amino acids

A wide range of chiral mono- and ditopic cyclodextrin-based receptors have been synthesized by CuI-catalyzed azide-alkyne cycloaddition starting from mono-6-azido-β-cyclodextrin and chiral amino acids. Of interest, microwaves proved very efficient to acce