875664-57-6

Basic information

• Product Name: 4,5-DIFLUORO-2-METHYLANILINE
• Synonyms: 4,5-DIFLUORO-2-METHYLANILINE;4,5-Difluoro-2-methylbenzenamine
• CAS NO: 875664-57-6
• Molecular Formula: C7H7F2N
• Molecular Weight: 143.13
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 875664-57-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 56-58°C
• Boiling Point: 216.2 °C at 760 mmHg
• Flash Point: 100 °C
• Appearance: light brown crystalline powder
• Density: 1.229 g/cm³
• Vapor Pressure: 0.142mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.49±0.10(Predicted)
• CAS DataBase Reference: 4,5-DIFLUORO-2-METHYLANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DIFLUORO-2-METHYLANILINE(875664-57-6)
• EPA Substance Registry System: 4,5-DIFLUORO-2-METHYLANILINE(875664-57-6)

Safety Data

• RIDADR: UN2811
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 875664-57-6(Hazardous Substances Data)

Usage

General Description

4,5-Difluoro-2-methylaniline is a chemical compound with the molecular formula C7H7F2N. It is an aromatic amine with two fluorine atoms and a methyl group attached to the benzene ring. 4,5-DIFLUORO-2-METHYLANILINE is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. It is also used in the production of organic compounds and as a building block in organic synthesis. 4,5-Difluoro-2-methylaniline is a colorless to yellow liquid with a slightly amine-like odor. It is important to handle this chemical with care as it can be harmful if ingested, inhaled, or comes into contact with the skin or eyes.

InChI:InChI=1/C7H7F2N/c1-4-2-5(8)6(9)3-7(4)10/h2-3H,10H2,1H3

Upstream product

• 127371-50-0 1,2-difluoro-4-methyl-5-nitrobenzene 
• 7494-45-3 1,2-dichloro-4-methyl-5-nitrobenzene 

Relevant articles and documents

Preparation method of 2,4,5-trifluorophenylacetic acid

The invention belongs to the technical field of preparation of drug intermediates, and discloses a preparation method of 2,4,5-trifluorophenylacetic acid, wherein the preparation method comprises the steps: step 1, reacting raw materials, a quaternary ammonium salt catalyst, sulfolane and potassium fluoride to obtain a first intermediate; step 2, carrying out hydrogenation catalytic reaction on the first intermediate to obtain a second intermediate; step 3, carrying out salt forming reaction on the second intermediate and a fluorinating reagent, quenching, and carrying out diazotization reaction on the second intermediate and a sodium nitrite aqueous solution to obtain diazonium salt; step 4, carrying out high-temperature cracking on the diazonium salt, to obtain 2,4,5-trifluorotoluene; and step 5 to step 7, carrying out halogenation, cyanidation and hydrolysis reactions on 2,4,5-trifluorotoluene in sequence, and thus obtaining 2,4,5-trifluorophenylacetic acid. The raw materials adopted by the method are easy to obtain and low in cost, the yield of the corresponding product obtained in each step is high, and large-scale production of the 2,4,5-trifluorophenylacetic acid is facilitated.