127371-50-0

Basic information

• Product Name: 4,5-DIFLUORO-2-NITROTOLUENE
• Synonyms: 4,5-DIFLUORO-2-NITROTOLUENE;2-Nitro-4,5-difluorotoluene;1,2-difluoro-4-methyl-5-nitrobenzene;4,5-Difluoro-2-methylnitrobenzene;4,5-Difluoro-2-methylnitrobenzene, 1,2-Difluoro-4-methyl-5-nitrobenzene
• CAS NO: 127371-50-0
• Molecular Formula: C₇H₅F₂NO₂
• Molecular Weight: 173.12
• Mol File: 127371-50-0.mol

Chemical Properties

• Boiling Point: 224.5 °C at 760 mmHg
• Flash Point: 97.9 °C
• Appearance: Colorless to pale yellow/Liquid
• Density: 1.374g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4,5-DIFLUORO-2-NITROTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DIFLUORO-2-NITROTOLUENE(127371-50-0)
• EPA Substance Registry System: 4,5-DIFLUORO-2-NITROTOLUENE(127371-50-0)

Safety Data

• Hazard Codes: Xi
• RIDADR: 2810
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 127371-50-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4,5-Difluoro-2-nitrotoluene is used as an intermediate in the synthesis of various pharmaceuticals for its unique chemical properties that can be utilized in the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical sector, 4,5-difluoro-2-nitrotoluene is employed as a precursor in the production of agrochemicals, contributing to the creation of compounds that can be used in pest control and crop protection.
Used in Organic Compounds Synthesis:
4,5-Difluoro-2-nitrotoluene is also used as a building block in the synthesis of other organic compounds, leveraging its reactive functional groups for the formation of diverse chemical entities in research and industrial applications.

Upstream product

• 7494-45-3 1,2-dichloro-4-methyl-5-nitrobenzene 
• 2927-34-6 3,4-difluorotoluene 

Downstream Products

• 887267-34-7 2,4,5-Trifluoro-toluene 
• 209995-38-0 (2,4,5-trifluorophenyl)acetic acid 
• 875664-57-6 4,5-difluoro-2-methylaniline 
• 931111-63-6 2-(2-fluoro-5-methyl-4-nitrophenyl)-1H-isoindole-1,3(2H)-dione 
• 20372-63-8 4,5-difluoro-2-nitrobenzoic acid 

Relevant articles and documents

Preparation method of 2,4,5-trifluorophenylacetic acid

The invention belongs to the technical field of preparation of drug intermediates, and discloses a preparation method of 2,4,5-trifluorophenylacetic acid, wherein the preparation method comprises the steps: step 1, reacting raw materials, a quaternary ammonium salt catalyst, sulfolane and potassium fluoride to obtain a first intermediate; step 2, carrying out hydrogenation catalytic reaction on the first intermediate to obtain a second intermediate; step 3, carrying out salt forming reaction on the second intermediate and a fluorinating reagent, quenching, and carrying out diazotization reaction on the second intermediate and a sodium nitrite aqueous solution to obtain diazonium salt; step 4, carrying out high-temperature cracking on the diazonium salt, to obtain 2,4,5-trifluorotoluene; and step 5 to step 7, carrying out halogenation, cyanidation and hydrolysis reactions on 2,4,5-trifluorotoluene in sequence, and thus obtaining 2,4,5-trifluorophenylacetic acid. The raw materials adopted by the method are easy to obtain and low in cost, the yield of the corresponding product obtained in each step is high, and large-scale production of the 2,4,5-trifluorophenylacetic acid is facilitated.

Intermediates for preparing 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid esters

Compounds of the formula: wherein Y is OR1, fluoro, chloro, methyl, R1, and R3 are independently selected from hydrogen and C1-C4 alkyl, R2 is C1-C4 alkyl and X is fluoro, chloro or bromo, with the proviso that when Y is OH, X cannot be bromo and with the proviso that X can be fluoro only if R2 is methyl.