127371-50-0

Basic information

• Product Name: 4,5-DIFLUORO-2-NITROTOLUENE
• Synonyms: 4,5-DIFLUORO-2-NITROTOLUENE;2-Nitro-4,5-difluorotoluene;1,2-difluoro-4-methyl-5-nitrobenzene;4,5-Difluoro-2-methylnitrobenzene;4,5-Difluoro-2-methylnitrobenzene, 1,2-Difluoro-4-methyl-5-nitrobenzene
• CAS NO: 127371-50-0
• Molecular Formula: C₇H₅F₂NO₂
• Molecular Weight: 173.12
• Mol File: 127371-50-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 224.5 °C at 760 mmHg
• Flash Point: 97.9 °C
• Appearance: Colorless to pale yellow/Liquid
• Density: 1.374g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4,5-DIFLUORO-2-NITROTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-DIFLUORO-2-NITROTOLUENE(127371-50-0)
• EPA Substance Registry System: 4,5-DIFLUORO-2-NITROTOLUENE(127371-50-0)

Safety Data

• Hazard Codes: Xi
• RIDADR: 2810
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 127371-50-0(Hazardous Substances Data)

Usage

General Description

4,5-Difluoro-2-nitrotoluene is a chemical compound that is commonly used in the production of pharmaceuticals, agrochemicals, and other organic compounds. It is a nitro derivative of toluene, containing two fluorine atoms in the 4 and 5 positions and a nitro group in the 2 position. This chemical is known for its strong aromatic odor and is typically found in the form of a colorless to pale yellow liquid. It is considered to be hazardous and can cause irritation to the skin, eyes, and respiratory system upon exposure. In addition, 4,5-difluoro-2-nitrotoluene is also a flammable substance and should be handled and stored with caution.

Upstream product

• 7494-45-3 1,2-dichloro-4-methyl-5-nitrobenzene 
• 2927-34-6 3,4-difluorotoluene 

Downstream Products

• 887267-34-7 2,4,5-Trifluoro-toluene 
• 209995-38-0 (2,4,5-trifluorophenyl)acetic acid 
• 875664-57-6 4,5-difluoro-2-methylaniline 
• 20372-63-8 4,5-difluoro-2-nitrobenzoic acid 
• 931111-63-6 2-(2-fluoro-5-methyl-4-nitrophenyl)-1H-isoindole-1,3(2H)-dione 

Relevant articles and documents

Preparation method of 2,4,5-trifluorophenylacetic acid

The invention belongs to the technical field of preparation of drug intermediates, and discloses a preparation method of 2,4,5-trifluorophenylacetic acid, wherein the preparation method comprises the steps: step 1, reacting raw materials, a quaternary ammonium salt catalyst, sulfolane and potassium fluoride to obtain a first intermediate; step 2, carrying out hydrogenation catalytic reaction on the first intermediate to obtain a second intermediate; step 3, carrying out salt forming reaction on the second intermediate and a fluorinating reagent, quenching, and carrying out diazotization reaction on the second intermediate and a sodium nitrite aqueous solution to obtain diazonium salt; step 4, carrying out high-temperature cracking on the diazonium salt, to obtain 2,4,5-trifluorotoluene; and step 5 to step 7, carrying out halogenation, cyanidation and hydrolysis reactions on 2,4,5-trifluorotoluene in sequence, and thus obtaining 2,4,5-trifluorophenylacetic acid. The raw materials adopted by the method are easy to obtain and low in cost, the yield of the corresponding product obtained in each step is high, and large-scale production of the 2,4,5-trifluorophenylacetic acid is facilitated.