875901-64-7Relevant articles and documents
CO2-expanded liquids as solvents to enhance activity of Pseudozyma antarctica lipase B towards ortho-substituted 1-phenylethanols
Hoang, Hai Nam,Koesoema, Afifa Ayu,Matsuda, Tomoko,Otsu, Moeko,Suzuki, Yuichi,Tamura, Mayumi
supporting information, (2020/09/18)
Pseudozyma (Candida) antarctica lipase B (CAL-B, Novozym 435) is one of the most widely used and outstanding biocatalysts. However, CAL-B-catalyzed transesterification of ortho-substituted 1-phenylethanol analogs suffers low conversion. In this research, the reactions were accelerated by using CO2-expanded liquids, liquids expanded by dissolving pressurized CO2, such as CO2-expanded hexane or CO2-expanded MeTHF.
Dynamic kinetic resolution of a wide range of secondary alcohols: Cooperation of dicarbonylchlorido(pentabenzylcyclopentadienyl)ruthenium and CAL-B
Paeivioe, Mari,Mavrynsky, Denys,Leino, Reko,Kanerva, Liisa T.
supporting information; experimental part, p. 1452 - 1457 (2011/04/22)
The substrate scope in the dynamic kinetic resolution ofsecondary alcohols was studied by using 31 structurallydifferent alcohols and isopropenyl acetate in the presence ofdicarbonylchlorido(pentabenzylcyclopentadienyl)rutheniumand Candida antarctica lipase B (Novozym 435, CAL-B) in toluene. The enzyme and the ruthenium complex were shown to function in a highly compatible manner allowing the conversion of the racemic alcohols into the (R)-acetates in practically theoretical yields and, in most cases, ee values exceeding 99%. The results are fully comparable to those published previously by using earlier reported, state-of-the-art ruthenium-based catalysts for the alcohol racemization. A clear benefit of the dicarbonylchlorido(pentabenzylcyclopentadienyl)ruthenium system, when compared to other (cyclopentadienyl)ruthenium racemization catalysts, is its simple and cost-efficient preparation. The substrate scope of 31 secondary alcohols was studied in the dynamic kinetic resolution by utilizing dicarbonylchlorido(pentabenzylcyclopentadienyl)rutheniumand Candida antarctica lipase B (CAL-B) in the acylation with isopropenyl acetate in toluene at room temperature. The secondary alcohols were transformed into highly enantiopure (R)-acetates (in most cases ee > 99%) in close to quantitative isolatedyields. Copyright
Single-step preparation of a 4-(dimethylamino)pyridine analogue bearing a sulfoxide as new chiral inducer. Preliminary evaluation as nucleophilic catalyst
Poisson, Thomas,Penhoat, Ma?l,Papamica?l, Cyril,Dupas, Georges,Dalla, Vincent,Marsais, Francis,Levacher, Vincent
, p. 2285 - 2288 (2007/10/03)
A one-step synthesis of a new chiral DMAP-1a equivalent is reported by bromine-magnesium exchange reaction of the 3-bromo-4-(dimethylamino)pyridine (2). The chiral sulfoxide appendage is introduced by trapping the resulting Grignard intermediate with (1R,
