876-98-2

Usage

InChI:InChI=1/C10H12O2/c1-7-5-4-6-8(2)10(7)12-9(3)11/h4-6H,1-3H3

Upstream product

• 576-26-1 2.6-dimethylphenol 
• 108-24-7 acetic anhydride 
• 463-51-4 Ketene 
• 2036-94-4 (dimethylamino)methyl acetate 
• 84511-65-9 bis-2,6-dimethyldiphenylsulfite 
• 830-03-5 4-nitrophenol acetate 
• 75-36-5 acetyl chloride 
• 151503-30-9 pentafluorobenzyl 2,6-dimethylphenyl ether 
• 108-22-5 Isopropenyl acetate 
• 438247-32-6 Ni(CH₃)OC₆H₃(CH₃)2(((CH₃)2CH)2P(CH₂)2P(CH(CH₃)2)2) 
• 201230-82-2 carbon monoxide 
• 438247-35-9 Ni(CH₃)OC₆H₃(CH₃)2(((CH₃)2CH)2P(CH₂)3P(CH(CH₃)2)2) 
• 438247-31-5 Ni(CH₂Si(CH₃)3)OC₆H₃(CH₃)2(((CH₃)2CH)2P(CH₂)2P(CH(CH₃)2)2) 
• 438247-34-8 Ni(CH₂Si(CH₃)3)OC₆H₃(CH₃)2(((CH₃)2CH)2P(CH₂)3P(CH(CH₃)2)2) 

Downstream Products

• 60041-69-2 acetic acid 2,6-bis(bromomethyl)phenyl ester 
• 4030-18-6 N-(acetyl)pyrrolidine 
• 576-26-1 2.6-dimethylphenol 
• 156451-04-6 2',6'-dimethylphenyl-<3-2H3>-propionate 
• 176243-28-0 2,6-(α,α,α',α'-tetrabromo)dimethylacetoxybenzene 
• 1450-72-2 5-methyl-2-hydroxyacetophenone 
• 261968-07-4 (Z)-(6S,7R,8S)-7-(tert-butyldimethylsilanyloxy)-9-(4-methoxybenzyloxy)-4,6,8-trimethylnon-4-enoic acid 2,6-dimethylphenyl ester 
• 51527-99-2 2,6-bis[N,N-di(2-hydroxyethyl)aminomethyl]phenol 
• 1004-66-6 2-methoxy-1,3-dimethylbenzene 
• 6994-64-5 3-amino-2,6-dimethyl-phenol 
• 6994-63-4 2,6-dimethyl-3-nitro-phenol 
• 58818-97-6 2,6-dimethyl-3-nitrophenyl acetate 
• 104216-50-4 (4-methoxy-3,5-dimethylphenyl)acetic acid 
• 60609-65-6 1-(4-methoxy-3,5-dimethylphenyl)ethanone 

Relevant academic research and scientific papers

Magnetically recyclable silica-coated ferrite magnetite-K10montmorillonite nanocatalyst and its applications in O, N, and S-acylation reaction under solvent-free conditions

Novel silica-coated ferrite nanoparticles supported with montmorillonite (K10) have been prepared successfully by using a simple impregnation method. Further, these nanoparticles were characterized by using different analytical methods like FT-IR, PXRD, EDS, and FE-SEM techniques. In addition, these nanoparticles have been explored for their catalytic activity for the O, N, and S-acylation reactions under solvent-free conditions which gave moderate to excellent yields in a much shorter reaction time. Moreover, these nanoparticles could easily be separated out from the reaction medium after the reaction completion by using an external magnetic field and have been re-used for 10 cycles without any significant loss of the catalytic activity.

Environmentally benign decarboxylative: N-, O-, and S-Acetylations and acylations

An operationally simple and general method for acetylation and acylation of a wide variety of substrates (amines, alcohols, phenols, thiols, and hydrazones) has been reported. Meldrum's acid and its derivatives have been used as an air-stable, non-volatile, cost-effective, and easy to handle acetylating/acylating agent. Easily separable byproducts (CO2 and acetone) allowed the isolation of analytically pure acetylated products without the requirement of work-up and any chromatography. This journal is

BROMODOMAIN INHIBITORS

The present invention provides for compounds of formula (I) wherein R1, R2, R3, R4, R6, X1, and X2 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).

Reusable and efficient polyvinylpolypyrrolidone-supported triflic acid catalyst for acylation of alcohols, phenols, amines, and thiols under solvent-free conditions

Abstract: A triflic acid-functionalized polyvinylpolypyrrolidone was prepared and fully characterized by FT-IR, TGA, and SEM. This super acidic solid catalyst shows high catalytic activity for selective acylation of alcohols, phenols, amines, and thiols with anhydrides under solvent-free conditions at room temperature. In addition, this method features an easy to handle solid super acid catalyst and an operationally simple procedure, affording the desired acylated products in excellent yields. Graphical abstract: [Figure not available: see fulltext.].

DMAP-based flexible polymer networks formed via Heck coupling as efficient heterogeneous organocatalysts

Two DMAP-based flexible polymer networks TPB-DMAP and TPA-DMAP have been successfully synthesized via palladium catalyzed Heck cross-coupling. The structures of these polymers were confirmed by solid state 13C CP/MAS and Fourier transform infrared spectroscopy (FTIR). Although both polymers have negligible surface areas, they exhibit excellent catalytic efficiency for the acylation of 1-phenylethanol with acetic anhydride due to their good swelling capacities. Utilized as a typical catalyst, the polymer TPA-DMAP shows high activities for acylation of a variety of alcohols to the corresponding esters. Moreover, the catalyst can be recycled at least ten times without obvious loss of catalytic activity.

Highly efficient and recyclable acetylation of phenols and alcohols by nickel zirconium phosphate under solvent-free conditions

Nickel zirconium phosphate nanoparticles have been used as an efficient catalyst for the acetylation of a wide range of alcohols and phenols with acetic anhydride in good to excellent yields under solvent-free conditions. The steric and electronic properties of the different substrates had a significant influence on the reaction conditions required to achieve the acetylation. The catalyst used in the current study was characterized by inductively coupled plasma optical emission spectroscopy, X-ray diffraction, N2 adsorption-desorption, scanning electron microscopy, and transmission electron microscopy. This nanocatalyst could also be recovered and reused at least six times without any discernible decrease in its catalytic activity.

Synthesis and biological evaluation of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists

Free fatty acid receptor 1 (FFA1) is a new potential drug target for the treatment of type 2 diabetes because of its role in amplifying glucose-stimulated insulin secretion in pancreatic β-cell. In the present studies, we identified phenoxyacetic acid derivative (18b) as a potent FFA1 agonist (EC50 = 62.3 nM) based on the structure of phenylpropanoic acid derivative 4p. Moreover, compound 18b could significantly improve oral glucose tolerance in ICR mice and dose-dependently reduced glucose levels in type 2 diabetic C57BL/6 mice without observation of hypoglycemic side effect. Additionally, compound 18b exhibited acceptable PK profiles. In summary, compound 18b with ideal PK profiles exhibited good activity in vitro and in vivo, and might be a promising drug candidate for the treatment of diabetes mellitus.

Acetylation of alcohols and phenols under solvent-free conditions using iron zirconium phosphate

Iron zirconium phosphate (ZPFe) nanoparticles were found to function as an efficient catalyst for the acetylation of a wide range of alcohols and phenols using acetic anhydride, generating good to excellent yields under solvent-free conditions. The steric and electronic properties of various substrates had a significant influence on the reaction conditions required to achieve the acetylation. The catalyst used in the current study was characterized by inductively coupled plasma-optical emission spectrometry, X-ray diffraction, N2 adsorption-desorption, scanning electron microscopy, and transmission electron microscopy. These analyses revealed that the interlayer distance in the catalyst increased from 7.5 to 9.3 ? when Fe3+ was intercalated between the layers, whereas the crystallinity of the material was reduced. This nanocatalyst could also be recovered and reused at least six times without any discernible decrease in its catalytic activity. This new method for the acetylation of alcohols and phenols has several important advantages, including mild and environmentally friendly reaction conditions, as well as good to excellent yields and a facile work-up.

Acetylation of alcohols and phenols by zinc zirconium phosphate as an efficient heterogeneous catalyst under solvent-free conditions

An efficient method for the acetylation of a wide range of alcohols as well as phenols with acetic anhydride in good to excellent yields under solvent-free conditions, using zinc zirconium phosphate as the catalyst was investigated. The catalyst was characterized by XRD, inductivity coupled plasma-optical emission spectroscopy, and scanning electron microscope. Products are easily isolated and the protocol is mild and green, compared to the existing methods. Graphical abstract: [Figure not available: see fulltext.]

Acetylation of alcohols and phenols under solvent-free conditions using copper zirconium phosphate

Copper zirconium phosphate nanoparticles have been used as an efficient catalyst for the acetylation of a wide range of alcohols and phenols with acetic anhydride in good to excellent yields under solvent-free conditions. The steric and electronic properties of the different substrates had a significant influence on the reaction conditions required to achieve the acetylation. The catalyst used in the current study was characterized by inductively-coupled plasma optical emission spectroscopy, energy dispersive spectroscopy, X-ray diffraction, N2 adsorption-desorption, scanning electron microscopy, and transmission electron microscopy. These analyses revealed that the interlayer distance in the catalyst increased from 7.5 to 8.0 ? when Cu2+ was intercalated between the layers, whereas the crystallinity of the material was reduced. This nanocatalyst could also be recovered and reused at least six times without any discernible decrease in its catalytic activity. This new method for the acetylation of alcohols and phenols has several key advantages, including mild and environmentally friendly reaction conditions, as well as good to excellent yields and a facile work-up.