87604-68-0

Upstream product

• 74074-09-2 Z-3-benzylidene-1-thiochromanone 
• 3528-17-4 2,3-dihydro-4H-[1]benzothiopyran-4-one 
• 100-52-7 benzaldehyde 

Downstream Products

• 109754-26-9 cis-4',5'-dihydro-4'-phenylspiro<2H-1-benzothiopyran-3(4H),3'-<3H>pyrazol>-4-one 
• 1333395-57-5 (2'R,3S,4'R,5'R)-methyl 2'-(4-chlorophenyl)-4-oxo-4'-phenylspiro[pyrrolidine-3,3'-thiochroman]-5'-carboxylate 
• 147375-47-1 C₁₇H₁₄N₂OS 

Relevant academic research and scientific papers

Facile condensation of aromatic aldehydes with chroman-4-ones and 1-thiochroman-4-ones catalysed by amberlyst-15 under microwave irradiation condition

Different aromatic aldehydes and cinnamaldehyde undergo crossaldol condensation with chroman-4-ones and 1-thiochroman-4-ones in the presence of amberlyst-15 under microwave irradiation in solvent free condition to afford rapidly the corresponding E-3-arylidene and E-3-cinnamylidene derivatives, respectively, in high yield. This process is simple, efficient and environmentally benign.

Synthesis and conformational analysis of some spiropyrazoline isomers

A series of spiropyrazolines has been synthesized by 1,3-dipolar cycloaddition of E- and Z-3-arylidene-chromanones, -1-thiochromanones, -flavanones, -1-thioflavanones as well as 2-benzylidene-1-indanone, -1-benzosuberone with diazomethane. It has been found that this cycloaddition is regio- and stereoselective affording trans- and cis- spiro-1-pyrazolines. Spiro-1-pyrazolines were converted into spiro-2-pyrazolines on acid-catalysed isomerization. Conformation and relative configuration of compounds prepared has been elucidated by various one- and two-dimensional n.m.r. methods.