876293-58-2Relevant academic research and scientific papers
Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists
Madsen-Duggan, Christina B.,Debenham, John S.,Walsh, Thomas F.,Toupence, Richard B.,Huang, Song X.,Wang, Junying,Tong, Xinchun,Lao, Julie,Fong, Tung M.,Schaeffer, Marie-Therese,Xiao, Jing Chen,Huang, Cathy R.-R.C.,Shen, Chun-Pyn,Stribling, D. Sloan,Shearman, Lauren P.,Strack, Alison M.,MacIntyre, D. Euan,Van der Ploeg, Lex H.T.,Goulet, Mark T.
, p. 2031 - 2035 (2008/02/02)
Optimization of the biological activity for 5,6-diarylpyridines as CB1 receptor inverse agonists is described. Food intake and pharmacokinetic evaluation of 3f and 15c indicate that these compounds are effective orally active modulators of CB1.
Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists
Debenham, John S.,Madsen-Duggan, Christina B.,Walsh, Thomas F.,Wang, Junying,Tong, Xinchun,Doss, George A.,Lao, Julie,Fong, Tung M.,Schaeffer, Marie-Therese,Xiao, Jing Chen,Huang, Cathy R.-R. C.,Shen, Chun-Pyn,Feng, Yue,Marsh, Donald J.,Stribling, D. Sloan,Shearman, Lauren P.,Strack, Alison M.,MacIntyre, D. Euan,Van Der Ploeg, Lex H. T.,Goulet, Mark T.
, p. 681 - 685 (2007/10/03)
Synthesis, SAR, and binding affinities are described for a new class of 1,8-naphthyridinone CB1 receptor specific inverse agonists. Food intake, knockout mouse, and pharmacokinetic evaluation of 14 indicate that this compound is an effective orally active
SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES
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Page/Page column 69, (2010/02/11)
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present in
