900254-46-8

Usage

Uses

Used in Pharmaceutical Industry:
(4-amino-2-(trifluoromethyl)phenyl)methanol is used as a building block for the synthesis of complex molecules, contributing to the development of new drugs. Its unique chemical structure and properties make it a valuable component in the creation of pharmaceutical compounds.
Used in Agrochemical Industry:
In the agrochemical sector, (4-amino-2-(trifluoromethyl)phenyl)methanol is utilized as a starting material for the synthesis of various herbicides and pesticides. Its incorporation into these products can enhance their effectiveness and selectivity, leading to improved agricultural outcomes.
It is crucial to note that due to potential health hazards associated with (4-amino-2-(trifluoromethyl)phenyl)methanol, it should be handled with care and only by professionals who adhere to proper safety protocols.

Upstream product

• 859027-06-8 (4-nitro-2-(trifluoromethyl)phenyl)methanol 
• 320-37-6 4-nitro-2-(trifluoromethyl)benzoic acid 
• 5308-25-8 4-ethylpiperazine 
• 876322-73-5 4-amino-2-(trifluoromethyl)benzaldehyde 
• 654-70-6 4-amino-2-trifluoromethylbenzonitrile 

Downstream Products

• 1096698-01-9 C₂₃H₂₁F₃N₆O₂ 
• 943319-70-8 ponatinib 

Relevant academic research and scientific papers

COMPOUNDS USEFUL FOR INHIBITING RAF DIMERS

The disclosure provides compounds of Formula I (Formula I) (c) And the pharmaceutically acceptable salts thereof. The A, B, C, and D rings and the variables, RA, RB, RC, RD, L0, L1, L2

UREA DERIVATIVE AND USE THEREFOR

The purpose of the present invention is to provide a compound with inhibitory activity on Discoidin Domain Receptor 1. The present invention provides a urea derivative represented by the formula (I) below or a pharmaceutically acceptable salt thereof.

UREA DERIVATIVE AND USE THEREFOR

The purpose of the present invention is to provide a compound with inhibitory activity on Discoidin Domain Receptor 1. The present invention provides a urea derivative represented by the formula below or a pharmaceutically acceptable salt thereof.

PROCESSES FOR MAKING PONATINIB AND INTERMEDIATES THEREOF

Methods are disclosed for making 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-l-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide, intermediates and pharmaceutically acceptable salts thereof.

NEW CHEMICAL COMPOUNDS

The present invention encompasses compounds of general formula (1), wherein the groups R1 to R3 and L are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and their use for

Syntheses of a triad of Flt3 kinase inhibitors: From bench to pilot plant

We have designed and developed an alternative synthesis for the manufacturing of a triad of Flt3 kinase inhibitors (AST487, ATH686, and AUZ454) to support clinical assessments of patients with Flt3-dependent tumor diseases. The new synthesis is convergent

Cinnamide and hydrocinnamide derivatives with kinase inhibitory activity

The present invention provides novel cinnamide compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various diseases.