876372-87-1Relevant academic research and scientific papers
A mild synthesis of [1,2,4]triazolo[4,3-a]pyridines
Schmidt, Michael A.,Qian, Xinhua
supporting information, p. 5721 - 5726 (2013/09/24)
The reaction between 2-hydrazinopyridines and ethyl imidates was examined as a one-pot method for rapidly preparing [1,2,4]triazolo[4,3-a]pyridines. A diverse set of 2-hydrazinopyridines were cyclized with a variety of alkyl- and aryl-substituted ethyl imidates in good yields. The reaction proceeds optimally under mild conditions (50-70 C) using 1.5 equiv of acetic acid. The electronic and steric properties of the hydrazine and imidate strongly impact the rate of the reaction. When highly electron deficient 2-hydrazinopyridines were used, the products rearranged to [1,2,4]triazolo[1,5-a]pyridines.
Continued exploration of the triazolopyridine scaffold as a platform for p38 MAP kinase inhibition
Jerome, Kevin D.,Rucker, Paul V.,Xing, Li,Shieh, Huey S.,Baldus, John E.,Selness, Shaun R.,Letavic, Michael A.,Braganza, John F.,McClure, Kim F.
scheme or table, p. 469 - 473 (2010/04/05)
The structure based drug design, synthesis and structure-activity relationship of a series of C6 sulfur linked triazolopyridine based p38 inhibitors are described. The metabolic deficiencies of this series were overcome through changes in the C6 linker fr
