876728-41-5Relevant academic research and scientific papers
7H-PYRROLO[2,3-D]PYRIMIDINE-4-AMINE DERIVATIVE
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Paragraph 0306, (2021/12/31)
The present invention provides a novel compound inhibiting EGFR or a salt of the compound. According to one embodiment of the present invention, provided is a compound represented by general formula (I) or a pharmaceutically acceptable salt thereof.
Synthesis of new fluorinated tebufenpyrad analogs with acaricidal activity through regioselective pyrazole formation
Fustero, Santos,Roman, Raquel,Sanz-Cervera, Juan F.,Simon-Fuentes, Antonio,Bueno, Jorge,Villanova, Salvador
experimental part, p. 8545 - 8552 (2009/04/05)
(Chemical Equation Presented) In previous studies, our group has shown that the use of fluorinated alcohols such as trifluoroethanol (TFE) and hexafluoroisopropanol (HFIP) as solvents dramatically increases the regioselectivity in the pyrazole formation from 1,3-diketone with methylhydrazine. We have now applied this synthetic method to the preparation of new fluorinated pyrazoles, which have then been used as synthetic intermediates in the preparation of fluorinated analogs of Tebufenpyrad, a commercial acaricide. These compounds display a strong acaricidal activity that is either comparable to or better than that of the commercial compound.
