87673-00-5

Upstream product

• 591-50-4 iodobenzene 
• 138823-76-4 3-Acetyl-1-ethoxycarbonyl-pyridinium; chloride 
• 350032-42-7 1,3-diacetyl-1,4-dihydro-4-phenylpyridine 
• 106-51-4 p-benzoquinone 
• 86801-40-3 1-phenoxycarbonylpyridinium chloride 
• 87672-90-0 4-Phenyl-4H-pyridine-1-carboxylic acid diethylamide 
• 100-59-4 phenylmagnesium chloride 
• 350-03-8 methyl-3-pyridylketone 
• 87673-08-3 3-Acetyl-4-phenyl-4H-pyridine-1-carboxylic acid diethylamide 

Downstream Products

• 1021864-90-3 C₂₀H₁₇N 

Relevant academic research and scientific papers

Regioselective formation of novel functionalized 1-aza-9-oxafluorenes

A small series of novel 1-aza-9-oxafluorenes have been prepared by regioselective cycloaddition reaction of p-benzoquinone to the sterically unhindered side of unsymmetrically substituted N-acyl-1,4-dihydropyridines (1). The stereochemistry of the product

Evaluation of the first cytostatically active 1-aza-9-oxafluorenes as novel selective CDK1 inhibitors with P-glycoprotein modulating properties

The first series of synthetic 1-aza-9-oxafluorenes with cytostatic activities in the micromolar range was evaluated as cyclin-dependent kinase (CDK1) inhibitors. Activity was found to be selective in comparison to the inhibition of other kinases within th

Regioselective Addition ofd Copper-Zinc Aryl Organometallic Reagents to 3-substituted Pyridinium Salts

A number of 3-substituted pyridinium salts are subjected to nucleophilic addition by copper-zinc aryl organometallic reagents.The adducts are oxidized subsequently to form the corresponding 4-arylpyridines.In all the cases 1,4-addition products are obtained predominantly.The regioselectivity can be rationalized according to the hard-soft acid-base principle.Calculations on both charge distributions and FMO coefficients indicate that these reactions may be classified on the basis of the type of soft acid-soft base reactions.The observed γ-attack complies very well with the orientation of the FMO coefficients as estimated by a semiempirical method.

SYNTHESIS OF 4-SUBSTITUTED 3-PYRIDYL KETONES

In the presence of a catalytic amount of cuprous iodide, the addition of Grignard reagents to the 1-phenoxycarbonyl salts of 3-acylpyridines gives 3-acyl-4-alkyl-1-phenoxycarbonyl-1,4-dihydropyridines.The crude dihydropyridines were aromatized with hot su

SYNTHESIS OF 3-ACYLPYRIDINES UTILIZING A FRIEDEL-CRAFTS REACTION

A synthesis of 3-acylpyridines via a Friedel-Crafts acylation of a dihydropyridine intermediate is described.