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Relevant academic research and scientific papers

Cupric oxide nanowires on three-dimensional copper foam for application in click reaction

Readily prepared CuO nanowires (CuO NWs) have been found to be effective heterogeneous catalysts for the 1,3-dipolar cycloaddition (CuAAC) reaction without using any additional support and bases. Examination of CuO nanowire catalysts synthesized at variou

Highly Efficient and Stable Atomically Dispersed Cu Catalyst for Azide-Alkyne Cycloaddition Reaction

In this study, we report a highly stable and efficient single-atom Cu dispersed on N-doped porous carbon as a superior catalyst for azide-alkyne cycloaddition reaction. A broad set of 1,4-disubstituted 1,2,3-triazoles was synthesized in high to excellent

Water as a solvent for Ru-catalyzed click reaction: Highly efficient recyclable catalytic system for triazolocoumarins synthesis

A new family of Ru (III) complexes has been synthesized, characterized and their catalytic performance has been tested for alkyne–azide cycloaddition (AAC) in water under ultrasonic irradiation conditions. These complexes are found to be effective heterog

Synthesis of a heterogeneous Cu(OAc)2-anchored SBA-15 catalyst and its application in the CuAAC reaction

A novel dinuclear Cu(OAc)2-anchored SBA-15 catalyst was synthesized by simple proton exchange of a carboxyl functionalized mesoporous SBA-15 silica with Cu(OAc)2 in water. XAFS and EPR spectra were utilized to probe its structure. Su

CuI/Et 2 NH-Catalyzed One-Pot Highly Efficient Synthesis of 1,4-Disubstituted 1,2,3-Triazoles in Green Solvent Glycerol

A concise one-pot three-component reaction of organic halides, terminal acetylenes, and sodium azide provided an efficient route for the synthesis of 1,2,3-triazoles. A variety of 1,2,3-triazoles were prepared in good to excellent yields with green solven

CuO-Nanoparticles Catalyzed Synthesis of 1,4-Disubstituted-1,2,3-Triazoles from Bromoalkenes

Abstract: A novel and efficient protocol involving commercially available CuO nanoparticles (CNP) as catalyst has been developed for the synthesis of 1,2,3-triazoles. A library of 1,4-disubstituted 1,2,3-triazoles has been constructed with good to excellent yields. Graphical Abstract: SynopsisA novel and efficient protocol involving commercially available CuO nanoparticles (CNP) as catalyst has been developed for the synthesis of 1,2,3-triazoles. A library of 1,4-disubstituted 1,2,3-triazoles has been constructed with good to excellent yields.[Figure not available: see fulltext.].

Synthesis of mono- and binuclear Cu(II) complexes bearing unsymmetrical bipyridine-pyrazole-amine ligand and their applications in azide-alkyne cycloaddition

Mono- and binuclear Cu(II) complexes bearing an unsymmetrical bipyridine-pyrazole-amine ligand were synthesized and characterized using X-ray diffraction. The mononuclear complex could be converted to the corresponding binuclear complexes under basic conditions due to the lability of the pyrazolyl N-H. Both complexes proved to be effective catalysts for azide-alkyne cycloaddition to form triazoles, with the binuclear complex exhibiting higher catalytic activity than the corresponding mononuclear one. The binuclear complex was effective at catalyst loadings as low as 0.0125 mol %, making it one of the most active catalysts for this reaction to date. Therefore, this catalyst was applied in the synthesis of potentially biologically active molecules. At 0.1-0.3 mol % catalyst loading, three precursors of Sorafenib analogs were synthesized in excellent yields. A one-pot variant of the reaction, generating the azide in situ, could also be performed using the binuclear complex as the catalyst. The transition metal complex bearing an unsymmetrical ligand may exhibit excellent catalytic activity, which represents a direction for developing new highly active catalysts.

Highly active binuclear Cu(II) catalyst bearing an unsymmetrical bipyridine-pyrazole-amine ligand for the azide-alkyne cycloaddition reaction

Ligands containing NH groups often show special characteristics. In this paper, a well-defined dinuclear Cu(II) complex bearing an unsymmetrical bipyridine-pyrazole-amine ligand was synthesized by the condensation of N–H to release H2O. Using sodium L-ascorbate as a reductant, the binuclear complex showed excellent activity in 1,3-dipolar cycloaddition reactions between alkynes and azides to obtain 1,4-disubstituted triazoles in 95%–99% isolated yields.

Silver nanoparticles embedded in modified polyallylamine resin as efficient catalysts for alkyne-azide 1,3-dipolar cycloaddition in water

A silver nanoparticle composite based on modified polyallylamine has been synthesized by a simple chemical route and its catalytic activity has been tested for alkyne-azide cycloaddition reaction. This silver nanocomposite shows an excellent catalytic activity at 80 °C for the synthesis of 1,4-disubstituted 1,2,3-triazole by alkyne-azide cycloaddition. The solid silver nanocomposite catalyst was characterized by transmission electron microscopy, Fourier-transform infrared spectroscopy, X-ray diffractometry and thermogravimetric analysis. The developed catalyst is stable in air, easy to prepare and can be recovered easily and reused ten times without a significant decrease in activity.

An efficient three-component reaction of sodium azide, haloalkane and alkyne for the synthesis of 1, 2, 3-triazoles catalyzed by the bifunctional ionic liquid catalyst choline chloride-CuCl in water

1, 2, 3-Triazoles were synthesized using a one-pot procedure via a three-component reaction between an organic halide, sodium azide and alkyne in the presence of an ionic liquid choline chloride-CuCl catalyst. The catalyst can increase the rate of the nucleophilic substitution reaction and showed a high catalytic activity for the [3+2] Huisgen cycloaddition in water. This method is applicable for a wide range of alkynes including aromatic and heterocyclic substrates.