876909-51-2Relevant academic research and scientific papers
Palladium-catalyzed oxidative acetoxylation of benzylic C-H bond using bidentate auxiliary
Ju, Long,Yao, Jinzhong,Wu, Zaihong,Liu, Zhanxiang,Zhang, Yuhong
, p. 10821 - 10831 (2013/11/19)
Pd(OAc)2-catalyzed oxidative acetoxylation of benzylic C-H bonds utilizing a bidentate system has been explored. A variety of picolinoyl- or quinoline-2-carbonyl-protected toluidine derivatives react with PhI(OAc) 2 in the presence of Pd(OAc)2 to afford the acetoxylated products in synthetically useful yields. A broad of functionalities, such as CH3, F, Cl, Br, I, COCH3, CO2Et, SO 2CH3, and NO2, were tolerated. This transformation provides easy access to 2-hydroxymethylaniline derivatives.
Pd-catalyzed arylation/oxidation of benzylic C-H bond
Xie, Yongju,Yang, Yuzhu,Huang, Lehao,Zhang, Xunbin,Zhang, Yuhong
supporting information; experimental part, p. 1238 - 1241 (2012/05/20)
A palladium-catalyzed benzylic C-H arylation/oxidation reaction leading to diaryl ketones has been accomplished. The indispensable role of the bidentate system is disclosed for this sequential process. This chemistry offers a direct new access to a range of diarylketones.
Challenges in the development of mGluR5 positive allosteric modulators: The discovery of CPPHA
Zhao, Zhijian,Wisnoski, David D.,O'Brien, Julie A.,Lemaire, Wei,Williams Jr., David L.,Jacobson, Marlene A.,Wittman, Marion,Ha, Sookhee N.,Schaffhauser, Herve,Sur, Cyrille,Pettibone, Doug J.,Duggan, Mark E.,Conn, P. Jeffrey,Hartman, George D.,Lindsley, Craig W.
, p. 1386 - 1391 (2007/10/03)
This Letter describes, for the first time, the synthesis and SAR, developed through an iterative analog library approach, that led to the discovery of the positive allosteric modulator (PAM) of the metabotropic glutamate receptor mGluR5 CPPHA. Binding to
