87692-41-9

Usage

InChI:InChI=1/C20H36O7/c1-2-3-4-6-13(21)9-10-14-15(18(24)12-17(14)23)11-19(25)16(22)7-5-8-20(26)27/h9-10,13-19,21-25H,2-8,11-12H2,1H3,(H,26,27)/b10-9+/t13-,14+,15+,16?,17+,18-,19?/m0/s1

Upstream product

• 87692-40-8 15α-O-(t-butyldimethylsilyl)-5,6-dihydro-5,6-dihydroxy-PGF_2α 
• 13345-50-1 prostaglandin A₂ 
• 31753-19-2 (5Z,13E)-15-hydroxy-9-oxoprosta 5,10,13 trien-1-oic acid 
• 53122-04-6 15α-O-t-butyldimethylsilyl-PGA₂ methyl ester 
• 87692-39-5 15α-O-(t-butyldimethylsilyl)-5,6-dihydro-5,6-dihydroxy-PGF_2α methyl ester 
• 87692-37-3 (Z)-7-{(1S,2R,3R,5S)-2-[(E)-(S)-3-(tert-Butyl-dimethyl-silanyloxy)-oct-1-enyl]-4-oxo-6-oxa-bicyclo[3.1.0]hex-3-yl}-hept-5-enoic acid methyl ester 
• 87692-38-4 15α-O-(t-butyldimethylsilyl)-PGE₂ methyl ester 
• 65147-38-8 15α-O-(t-butyldimethylsilyl)-PGF_2α methyl ester 

Relevant academic research and scientific papers

Synthesis of Aromatic Modified Prostaglandins from PGA2

A general synthetic scheme, starting from PGA2 (obtained from the marine coral Plexaura homomalla), of prostaglandins modified in the upper chain is detailed.Key aldehyde intermediates have been secured from 11-deoxy-PGF2α and PGF2α by an efficient regioselective hydroxylation procedure followed by cleavage of the 5,6-double bond.Witting reaction with these aldehydes provided the novel prostaglandins (5)-(8), belonging to the E and F families, and containing an aromatic ring in the upper chain.