876954-45-9

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 188659-92-9 (S)-2-(tert-butyldimethylsilyloxy)-N,N-tetramethylenepropanamide 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 876954-49-3 (2S,4R)-5-(benzyloxy)-2,4-dimethylpentanal 
• 876954-47-1 (2S,4R,5S,6S,8R)-9-benzyloxy-2-(tert-butyldimethylsilyloxy)-4-ethyl-5-hydroxy-6,8-dimethyl-3-nonanone 
• 876954-55-1 (2S,4R,5S,6S,8R)-9-benzyloxy-2,5-di(tert-butyldimethylsilyloxy)-4-ethyl-6,8-dimethyl-3-nonanone 

Relevant academic research and scientific papers

Highly stereoselective titanium-mediated aldol reactions from chiral α-silyloxy ketones. A reliable tool for the synthesis of natural products

Chiral α-silyloxy ketones participate in highly stereoselective TiCl4-mediated aldol reactions that afford diastereomerically pure syn-syn adducts in high yield irrespective of the R1 and R 2 substituents flanking the carbonyl or the silicon protecting group. Further manipulation of the resulting aldol adducts provide in a straightforward manner highly functionalized fragments that facilitate the synthesis of natural products.

Stereoselective synthesis of the western hemisphere of salinomycin

A convergent and module-based strategy for the asymmetric synthesis of the western hemisphere (C1-C17 fragment) of salinomycin has been devised. This new synthetic approach relies on highly stereoselective C-glycosidation and aldol processes.