87699-02-3Relevant academic research and scientific papers
Photoredox α-vinylation of α-amino acids and N -aryl amines
Noble, Adam,MacMillan, David W. C.
supporting information, p. 11602 - 11605 (2014/11/08)
A new coupling protocol has been developed that allows the union of vinyl sulfones with photoredox-generated α-amino radicals to provide allylic amines of broad diversity. Direct C-H vinylations of N-aryl tertiary amines, as well as decarboxylative vinylations of N-Boc α-amino acids, proceed in high yield and with excellent olefin geometry control. The utility of this new allyl amine forming reaction has been demonstrated via the syntheses of several natural products and a number of established pharmacophores.
"tert-Amino Effect" in Heterocyclic Synthesis. Formation of N-Heterocycles by Ring-Closure Reactions of Substituted 2-Vinyl-N,N-dialkylanilines
Verboom, Willem,Reinhoudt, David N.,Visser, Richard,Harkema, Sybolt
, p. 269 - 276 (2007/10/02)
2-Vinyl-N,N-dialkylanilines react thermally in polar solvents and/or in the presence of Lewis acids via or hydrogen transfer followed by C-C bond formation to give heterotricyclic compounds.The reaction depends on the type of N,N-dialkylamino
