877165-61-2

Upstream product

• 695179-07-8 N-(3-amino-5-tert-butyl-2-methoxy-phenyl)-methanesulphonamide hydrochloride 
• 877165-58-7 7-formyl-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide 
• 1215385-15-1 7-formyl-1-methyl-1H-indole-2-carboxylic acid 
• 404010-35-1 N-(3-amino-5-tert-butyl-2-methoxy-phenyl)-methanesulfonamide 
• 50709-33-6 2-bromophenylhydrazine hydrochloride 
• 16732-66-4 2-bromophenylhydrazine 
• 16732-69-7 ethyl 7-bromo-1H-indole-2-carboxylate 
• 908135-49-9 7-bromo-1-methyl-1H-indole-2-carboxylic acid 
• 908135-63-7 ethyl 7-bromo-1-methyl-1H-indole-2-carboxylate 
• 1215385-50-4 7-bromo-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide 
• 1215385-55-9 7-hydroxymethyl-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide 
• 1215385-59-3 methyl 2-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indole-7-carboxylate 

Downstream Products

• 1215384-50-1 1-methyl-7-[4-(1-methyl-piperidine-3-carbonyl)-piperazin-1-ylmethyl]-1H-indole-2-carboxylic acid (5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide 
• 1215384-46-5 (R)-7-[4-(3-dimethylamino-pyrrolidine-1-carbonyl)-piperazin-1-ylmethyl]-1-methyl-1H-indole-2-carboxylic acid (5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide 
• 1215385-23-1 tert-butyl 3-{4-[2-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indol-7-ylmethyl]-piperazine-1-carbonyl}-azetidine-1-carboxylate 
• 1215384-10-3 1-methyl-7-[4-(1-methyl-piperidine-4-carbonyl)-piperazin-1-ylmethyl]-1H-indole-2-carboxylic acid (5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide 
• 1215384-48-7 7-[4-(azetidine-3-carbonyl)-piperazin-1-ylmethyl]-1-methyl-1H-indole-2-carboxylic acid (5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide 
• 1215384-57-8 7-{4-[2-(4-dimethylamino-piperidin-1-yl)-acetyl]-piperazin-1-ylmethyl}-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide 

Relevant academic research and scientific papers

7-(Piperazine-1-Ymethyl)-1H-Indole-2-Carboxylic Acid (Phenyl)-Amide Derivatives and Allied Compounds as P38 Map Kinase Inhibitors for the Treatment of Respiratory Diseases

The present invention provides compounds according to general formula (I) which are proposed for the treatment of respiratory complaints, particularly asthma and COPD.

Cytokine inhibitors

Disclosed are compounds of formula (I) which inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclos