877279-19-1

Basic information

• Product Name: 1-(4-carboxybutyl)-3-cyclohexyl-1H-indole-6-carboxylic acid
• Synonyms: 1-(4-carboxybutyl)-3-cyclohexyl-1H-indole-6-carboxylic acid
• CAS NO: 877279-19-1
• Molecular Weight: 343.423
• Mol File: 877279-19-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-carboxybutyl)-3-cyclohexyl-1H-indole-6-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-carboxybutyl)-3-cyclohexyl-1H-indole-6-carboxylic acid(877279-19-1)
• EPA Substance Registry System: 1-(4-carboxybutyl)-3-cyclohexyl-1H-indole-6-carboxylic acid(877279-19-1)

Safety Data

• Hazardous Substances Data: 877279-19-1(Hazardous Substances Data)

Upstream product

• 5454-83-1 5-bromovaleric acid methyl ester 
• 494799-19-8 methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate 
• 494799-18-7 methyl 3-cyclohexyl-1H-indole-6-carboxylate 
• 877279-12-4 methyl 3-cyclohexyl-1-(5-methoxy-5-oxopentyl)-1H-indole-6-carboxylate 

Downstream Products

• 877279-26-0 11-cyclohexyl-10-oxo-7,8,9,10-tetrahydro-6H-azepino[1,2-a]indole-3-carboxylic acid 
• 877279-33-9 9-bromo-11-cyclohexyl-10-oxo-7,8,9,10-tetrahydro-6H-azepino[1,2-a]indole-3-carboxylic acid 

Relevant articles and documents

The synthesis of novel heteroaryl-fused 7,8,9,10-tetrahydro-6H-azepino[1,2- a]indoles, 4-oxo-2,3-dihydro-1H-[1,4]diazepino[1,7-a]indoles and 1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indoles. Effective inhibitors of HCV NS5B polymerase

Three synthetic approaches have been developed that allow efficient access to novel heteroaryl fused indole ring systems, including: 7,8,9,10-tetrahydro- 6H-azepino[1,2-a]indoles, 4-oxo-2,3-dihydro-1H-[1,4]diazepino[1,7-a]indoles and 1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indoles. Each strategy is fully exemplified and the relative merits and limitations of the approaches are discussed. The hepatitis C virus (HCV) non-structural 5B (NS5B) polymerase inhibitory activities of select examples from each molecular class are briefly presented.