494799-18-7

Basic information

• Product Name: 3-CYCLOHEXYL-1H-INDOLE-6-CARBOXYLIC ACID METHYL ESTER
• Synonyms: 3-CYCLOHEXYL-1H-INDOLE-6-CARBOXYLIC ACID METHYL ESTER;Methyl 3-cyclohexyl-1H-indole-6-carboxylate;1H-Indole-6-carboxylic acid, 3-cyclohexyl-, Methyl ester;METHYL 3-CYCLOHEXYL-1H-INDOLE-6-CARBOXYLATE(WXG03104)
• CAS NO: 494799-18-7
• Molecular Formula: C₁₆H₁₉NO₂
• Molecular Weight: 257.32756
• Mol File: 494799-18-7.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 431.6 °C at 760 mmHg
• Flash Point: 214.8 °C
• Appearance: /
• Density: 1.164 g/cm³
• Vapor Pressure: 1.18E-07mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-CYCLOHEXYL-1H-INDOLE-6-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CYCLOHEXYL-1H-INDOLE-6-CARBOXYLIC ACID METHYL ESTER(494799-18-7)
• EPA Substance Registry System: 3-CYCLOHEXYL-1H-INDOLE-6-CARBOXYLIC ACID METHYL ESTER(494799-18-7)

Safety Data

• Hazardous Substances Data: 494799-18-7(Hazardous Substances Data)

Usage

General Description

3-CYCLOHEXYL-1H-INDOLE-6-CARBOXYLIC ACID METHYL ESTER is a chemical compound with a molecular formula C16H21NO2. It is a methyl ester derivative of 3-cyclohexyl-1H-indole-6-carboxylic acid and belongs to the class of indole compounds. This chemical is commonly used in the pharmaceutical and agrochemical industries, where it serves as an intermediate for the synthesis of various drugs and agricultural products. Its structure and properties make it suitable for use in organic synthesis and as a building block for the production of complex organic molecules.

InChI:InChI=1/C16H19NO2/c1-19-16(18)12-7-8-13-14(10-17-15(13)9-12)11-5-3-2-4-6-11/h7-11,17H,2-6H2,1H3

Upstream product

• 494799-17-6 3-cyclohexyl-1-methyl-1H-indole-6-carboxylic acid 
• 74-88-4 methyl iodide 
• 1670-82-2 Indole-6-carboxylic acid 
• 108-94-1 cyclohexanone 
• 67-56-1 methanol 
• 494799-19-8 methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate 
• 73183-34-3 bis(pinacol)diborane 
• 50820-65-0 indole-6-carboxylic acid methyl ester 
• 494799-16-5 3-(cyclohex-1-en-1-yl)-1H-indole-6-carboxylic acid 
• 774213-78-4 methyl 3-cyclohex-2-en-1-yl-1H-indole-6-carboxylate 

Downstream Products

• 494799-22-3 2-bromo-3-cyclohexyl-1-methylindole-6-carboxylic acid methyl ester 
• 494799-77-8 3-cyclohexyl-2-furan-3-yl-1-methyl-1H-indole-6-carboxylic acid 
• 494799-19-8 methyl 2-bromo-3-cyclohexyl-1H-indole-6-carboxylate 
• 877279-19-1 1-(4-carboxybutyl)-3-cyclohexyl-1H-indole-6-carboxylic acid 
• 877279-26-0 11-cyclohexyl-10-oxo-7,8,9,10-tetrahydro-6H-azepino[1,2-a]indole-3-carboxylic acid 
• 877272-52-1 methyl 1-allyl-3-cyclohexyl-2-(2-vinylpyridin-3-yl)-1H-indole-6-carboxylate 
• 877279-33-9 9-bromo-11-cyclohexyl-10-oxo-7,8,9,10-tetrahydro-6H-azepino[1,2-a]indole-3-carboxylic acid 

Relevant articles and documents

HEPATITIS B CORE PROTEIN MODULATORS

The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound of formula:

Bronsted acid ionic liquid-catalyzed reductive Friedel-Crafts alkylation of indoles and cyclic ketones without using an external reductant

In the absence of an external reductant, C3-cycloalkylated indole could be synthesized through reductive alkylation of indole with cyclic ketone using a sulfonyl-functionalized Bronsted acid ionic liquid as a catalyst. Water generated in the initial stage of the reaction played a key role in rendering the reductive coupling possible. The reaction proceeds most likely in a radical way.

The synthesis of novel heteroaryl-fused 7,8,9,10-tetrahydro-6H-azepino[1,2- a]indoles, 4-oxo-2,3-dihydro-1H-[1,4]diazepino[1,7-a]indoles and 1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indoles. Effective inhibitors of HCV NS5B polymerase

Three synthetic approaches have been developed that allow efficient access to novel heteroaryl fused indole ring systems, including: 7,8,9,10-tetrahydro- 6H-azepino[1,2-a]indoles, 4-oxo-2,3-dihydro-1H-[1,4]diazepino[1,7-a]indoles and 1,2,4,5-tetrahydro-[1,4]oxazepino[4,5-a]indoles. Each strategy is fully exemplified and the relative merits and limitations of the approaches are discussed. The hepatitis C virus (HCV) non-structural 5B (NS5B) polymerase inhibitory activities of select examples from each molecular class are briefly presented.