877289-97-9Relevant academic research and scientific papers
Synthesis of novel flavone acyl esters and correlation of log P value with antioxidant and antimicrobial activity
Jayashree,Thejaswini,Nayak, Yogendra,Kumar, D. Vijay
, p. 1055 - 1066 (2012/03/26)
Three series of flavones namely 6-hydroxy flavone, 6-chloro-3-hydroxy flavone, 3,6-dihydroxy flavone were synthesized. They were further benzoylated with different aromatic acid chlorides in the presence of pyridine gave three of acyl esters series (SCF 1 to 8, SHF 1 to 8 and SDF 1 to 8). The yields of all the substituted flavones were found satisfactory. These compounds were purified, characterized by their spectral data. log P and pKa value. They were screened for in vitro radical (DPP?) scavenging activity, showed appreciable activity. 7 compounds showed antimicrobial activity against Gram-positive bacteria. Further, the MIC values of these 7 compounds were also determined. All the compounds showing antioxidant activity also showed antibacterial activity. The relationship between log P, antioxidant and antibacterial activity was established.
