877383-54-5

Usage

Uses

Used in Pharmaceutical Industry:
Pyrrolidine, 1-(4-bromo-2-chlorobenzoyl)is used as a building block for the synthesis of various pharmaceuticals. Its unique structure and properties make it a valuable intermediate in the production of drugs and other bioactive molecules.
Used in Agrochemical Industry:
Pyrrolidine, 1-(4-bromo-2-chlorobenzoyl)is also used as a building block for the synthesis of various agrochemicals. Its aromatic ring containing bromine and chlorine atoms, as well as a pyrrolidine ring, contribute to its potential applications in this field.
Used in Material Development:
Pyrrolidine, 1-(4-bromo-2-chlorobenzoyl)has potential applications in the development of new materials. Its unique structure and properties can be utilized to create innovative materials with specific characteristics.
Used in Chemical Process Development:
Pyrrolidine, 1-(4-bromo-2-chlorobenzoyl)can be used in the development of new chemical processes. Its properties as a building block for various compounds make it a valuable asset in creating new and efficient chemical processes.

Upstream product

• 123-75-1 pyrrolidine 
• 59748-90-2 4-Bromo-2-chloro-benzoic Acid 
• 21900-55-0 4-bromo-2-chlorobenzoyl chloride 

Downstream Products

• 935841-13-7 3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-3-hydroxycyclobutanecarboxylic acid 
• 1337536-82-9 N-({trans-3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-cyclobutyl}methyl)-N-methylacetamide hydrochloroic acid 
• 1337536-66-9 N-({trans-3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-cyclobutyl}methyl)-N-methylacetamide 
• 1337536-68-1 1-{trans-3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-cyclobutyl}-N-methylmethanamine 
• 935839-86-4 trans-3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-methylcyclobutanecarboxamide 
• 935839-76-2 cis-3-[3-chloro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-methylcyclobutanecarboxamide 

Relevant academic research and scientific papers

Discovery of two clinical histamine H3 receptor antagonists: Trans - N -ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl] cyclobutanecarboxamide (PF-03654746) and trans -3-fluoro-3-[3-fluoro-4- (pyrrolidin-1-ylmethyl)phenyl]- N -(2-methy

The discovery of two histamine H3 antagonist clinical candidates is disclosed. The pathway to identification of the two clinical candidates, 6 (PF-03654746) and 7 (PF-03654764) required five hypothesis driven design cycles. The key to success i

COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE

A compound of formula (I) and salts thereof are provided: wherein A is defined in the specification. Processes for preparation, pharmaceutical compositions, and uses thereof as a medicament, for example in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.

HISTAMINE-3 RECEPTOR ANTAGONISTS

This invention is directed to a compound of formula Ias defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a process of preparation of a compound of formula I, a method of treatment of a disorder or condition that may be treated by antagonizing histamine H3 receptors, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above, and a method of treatment of a disorder or condition selected from the group consisting of depression, mood disorders, schizophrenia, anxiety disorders, Alzheimer's disease, attention-deficit hyperactivity disorder (ADHD), psychotic disorders, cognitive disorders, sleep disorders, obesity, dizziness, epilepsy, motion sickness, respiratory diseases, allergy, allergy- induced airway responses, allergic rhinitis, nasal congestion, allergic congestion, congestion, hypotension, cardiovascular disease, diseases of the GI tract, hyper and hypo motility and acidic secretion of the gastro- intestinal tract, the method comprising administering to a mammal in need of such treatment a compound of formula I as described above.

BIPHENYLOXYACETIC ACID DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASE

The invention relates to substituted phenoxyacetic acids of formula (I), where the variables are as defined in claim 1, as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.