87740-05-4

Upstream product

• 100-02-7 4-nitro-phenol 
• 2417-72-3 Methyl 4-(bromomethyl)benzoate 
• 324544-87-8 methyl 4-[(4'-nitrophenoxy)methyl]benzoate 

Downstream Products

• 87740-09-8 4-<(4-nitrophenoxy)methyl>benzamide 
• 87739-53-5 4-[4-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1-yl)-phenoxymethyl]-benzamide; hydrochloride 
• 771431-29-9 4-(4-Amino-phenoxymethyl)-benzamide 

Relevant academic research and scientific papers

Design, synthesis and biological evaluation of novel hydroxamates and 2-aminobenzamides as potent histone deacetylase inhibitors and antitumor agents

Many studies have indicated that histone deacetylase (HDAC) inhibitors are promising agents for the treatment of cancer. With the aim to search for novel potent HDAC inhibitors, we designed and synthesized two series of hydroxamates and 2-aminobenzamides

Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines

The inhibition of dihydrofolate reductase fron chicken liver and from Lactobacillus casei has been studied with 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines. It was found that for the chicken enzyme, inhibitor potency for 101 triazines was correlated by a given equation. The mathematical models obtained from correlation analysis are compared with stereo color graphics models.