87740-09-8Relevant academic research and scientific papers
Solid phase synthesis of aryl ethers via the Mitsunobu reaction
Rano, Thomas A.
, p. 3789 - 3792 (2007/10/02)
A procedure for the preparation of aryl ethers on a solid support employing the Mitsunobu reaction is described. Either polymer bound phenols or benzyl alcohols react rapidly and cleanly with TMAD/Bu3P and the appropriate electrophile/nucleophile to provide the aryl ether in excellent yield and purity after cleavage from the solid support.
Crystallography, quantitative structure-activity relationships, and molecular graphics in a comparative analysis of the inhibition of dihydrofolate reductase from chicken liver and Lactobacillus casei by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines
Hansch,Hathaway,Guo,et al.
, p. 129 - 143 (2007/10/02)
The inhibition of dihydrofolate reductase fron chicken liver and from Lactobacillus casei has been studied with 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(substituted-phenyl)-s-triazines. It was found that for the chicken enzyme, inhibitor potency for 101 triazines was correlated by a given equation. The mathematical models obtained from correlation analysis are compared with stereo color graphics models.
