87742-50-5Relevant academic research and scientific papers
Investigations on Gold-Catalyzed Thioalkyne Activation Toward Facile Synthesis of Ketene Dithioacetals
Ye, Xiaohan,Wang, Jin,Ding, Shengtao,Hosseyni, Seyedmorteza,Wojtas, Lukasz,Akhmedov, Novruz G.,Shi, Xiaodong
, p. 10506 - 10510 (2017)
Nucleophilic addition to thioalkynes was investigated under various catalytic conditions with gold(I) complexes being identified as the optimal catalysts. Structural evaluation of the product revealed an unexpected cis-addition, arising from a gold-associated thioketene intermediate. Based on this interesting mechanistic insight, a gold(I)-catalyzed thioether addition to thioalkynes was developed as a novel approach to prepare ketene dithioacetals with good yields and high efficiency.
A useful method for preparation of carboxylic acids from terminal alkynes
Abrams, Suzanne R.
, p. 2423 - 2424 (2007/10/02)
Substituted acetic acids can be prepared in good yield (50-80percent) from terminal acetylenes of the same chain length.The alkyne is first converted to the thiophenyl ether, which is treated without purification with mercuric sulfate in acetic acid and 2N sulfuric acid affording the carboxylic acid.The method is particularly useful in the synthesis of long chain ω-hydroxyalkanoic acids.
