877624-37-8Relevant articles and documents
GPR40 AGONISTS
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Paragraph 00258, (2020/12/11)
This disclosure is directed, at least in part, to GPR40 agonists useful for the treatment of conditions or disorders involving the gut-brain axis. In some embodiments, the GPR40 agonists are gut-restricted compounds. In some embodiments, the GPR40 agonists are full agonists or partial agonists. In some embodiments, the condition or disorder is a metabolic disorder, such as diabetes, obesity, nonalcoholic steatohepatitis (NASH), or a nutritional disorder such as short bowel syndrome.
Total synthesis of (-)-martinellic acid via radical addition-cyclization- elimination reaction
Shirai, Atsushi,Miyata, Okiko,Tohnai, Norimitsu,Miyata, Mikiji,Procter, David J.,Sucunza, David,Naito, Takeaki
, p. 4464 - 4475 (2008/09/21)
(Chemical Equation Presented) The asymmetric total synthesis of martinellic acid, the first pyrrolo[3,2-c]quinoline alkaloid found in nature, is described. Three key steps in our synthesis of (-)-martinellic acid are the Bu 3SnH-promoted radica
2-SULFANYL-BENZOIMIDAZOL-1-YL-ACETIC ACID DERIVATIVES AS CRTH2 ANTAGONISTS
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Page/Page column 97, (2010/10/20)
The invention relates to 2-sulfanyl-benzoimidazol-1-yl-acetic acid derivatives and their use as potent "chemoattractant receptor-homologous molecule expressed on Th2 cells" antagonists in the treatment of prostaglandin mediated diseases, to pharmaceutical compositions containing these derivatives and to processes for their preparation.