877675-72-4

Basic information

• Product Name: 2-Cyclopropen-1-one, 2,3-bis(1-methylethyl)-
• CAS NO: 877675-72-4
• Molecular Formula: C9H14O
• Molecular Weight: 138.21
• Mol File: 877675-72-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Cyclopropen-1-one, 2,3-bis(1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclopropen-1-one, 2,3-bis(1-methylethyl)-(877675-72-4)
• EPA Substance Registry System: 2-Cyclopropen-1-one, 2,3-bis(1-methylethyl)-(877675-72-4)

Safety Data

• Hazardous Substances Data: 877675-72-4(Hazardous Substances Data)

Upstream product

• 69151-13-9 C₃Cl₂(C₃H₇)2 
• 124-07-2 Octanoic acid 
• 79-31-2 isobutyric Acid 
• 65-85-0 benzoic acid 
• 75-98-9 Trimethylacetic acid 

Relevant articles and documents

Nucleophilic acyl substitution via aromatic cation activation of carboxylic acids: Rapid generation of acid chlorides under mild conditions

The first example of aromatic cation-activated nucleophilic acyl substitution has been achieved. The conversion of carboxylic acids to their corresponding acid chlorides occurs rapidly in the presence of 3,3-dichlorocyclopropenes via the intermediacy of cyclopropenium carboxylate complexes. The effect of cyclopropene substituents on the rate of conversion is examined. The addition of tertiary amine base is found to dramatically accelerate reaction, and conditions were developed for the preparation of acid sensitive acid chlorides. Preparative scale peptide couplings of two N-Boc amino acids were achieved with this method.