87769-59-3Relevant academic research and scientific papers
Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as peripheral benzodiazepine receptor ligands: Synthesis, biological evaluation and 3D-QSAR investigation
Selleri, Silvia,Gratteri, Paola,Costagli, Camilla,Bonaccini, Claudia,Costanzo, Annarella,Melani, Fabrizio,Guerrini, Gabriella,Ciciani, Giovanna,Costa, Barbara,Spinetti, Francesca,Martini, Claudia,Bruni, Fabrizio
, p. 4821 - 4834 (2007/10/03)
The present paper reports the synthesis and binding studies of new 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as selective Peripheral Benzodiazepine Receptor (PBR) ligands. The variability of substituents at the 3-position was investigated and a 3D-
Structure-activity relationships in carboxamide derivatives based on the targeted delivery of radionuclides and boron atoms by means of peripheral benzodiazepine receptor ligands
Cappelli, Andrea,Mohr, Galla Pericot,Gallelli, Andrea,Giuliani, Germano,Anzini, Maurizio,Vomero, Salvatore,Fresta, Massimo,Porcu, Patrizia,Maciocco, Elisabetta,Concas, Alessandra,Biggio, Giovanni,Donati, Alessandro
, p. 3568 - 3571 (2007/10/03)
The structure-activity relationship studies on 2-quinolinecarboxamide peripheral benzodiazepine receptor (PBR) ligands have been refined with the aim of using these ligands as carriers of radionuclides and boron atoms. Some new ligands show enhanced affinity and steroidogenic activity with respect to reference compound 1 and are interesting candidates for radiolabeling and PET studies. Moreover, carborane derivative 3q, representing the first example of PBR ligand bearing a carborane cage, can be useful to explore an alternative mechanism in BNCT.
