877815-01-5Relevant academic research and scientific papers
Substituted 4-hydroxyphenyl sulfonamides as pathway-selective estrogen receptor ligands
Sabatucci, Joseph P.,Ashwell, Mark A.,Trybulski, Eugene,O'Donnell, Mary-Margaret,Moore, William J.,Harnish, Douglas C.,Chadwick, Christopher C.
, p. 854 - 858 (2007/10/03)
The transcription factor nuclear factor-κB (NF-κB) is a key component in the onset of inflammation. We describe here a series of 4-hydroxyphenyl sulfonamide estrogen receptor (ER) ligands that selectively inhibit NK-κB transcriptional activity but are devoid of conventional estrogenic activity.
