87789-47-7

Basic information

• Product Name: 4-(DIFLUOROMETHOXY)PHENOL
• Synonyms: 4-(DIFLUOROMETHOXY)PHENOL;4-(Difluoromethoxy)phenol 98%;4-(Difluoromethoxy)phenol98%;alpha,alpha-Difluoro-4-hydroxyanisole, Difluoromethyl 4-hydroxyphenyl ether
• CAS NO: 87789-47-7
• Molecular Formula: C₇H₆F₂O₂
• Molecular Weight: 160.12
• Mol File: 87789-47-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 225.2 °C at 760 mmHg
• Flash Point: 111.6 °C
• Appearance: /
• Density: 1.3 g/cm³
• Vapor Pressure: 0.0584mmHg at 25°C
• Refractive Index: 1.481
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 9.52±0.15(Predicted)
• CAS DataBase Reference: 4-(DIFLUOROMETHOXY)PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(DIFLUOROMETHOXY)PHENOL(87789-47-7)
• EPA Substance Registry System: 4-(DIFLUOROMETHOXY)PHENOL(87789-47-7)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25
• Safety Statements: 45
• Hazardous Substances Data: 87789-47-7(Hazardous Substances Data)

Usage

General Description

4-(Difluoromethoxy)phenol, also known as 4-DFMP, is a chemical compound with the molecular formula C7H6F2O2. It is a white solid substance that is used as an intermediate in the synthesis of various pharmaceutical drugs and agrochemicals. 4-DFMP is a phenolic compound that contains two fluorine atoms attached to a methoxy group, giving it a unique and useful chemical structure. It is often used as a building block in organic synthesis and is also being investigated for its potential biological activity in the treatment of various diseases. Overall, 4-(difluoromethoxy)phenol is a versatile and important chemical compound with applications in both the pharmaceutical and agricultural industries.

InChI:InChI=1/C7H6F2O2/c8-7(9)11-6-3-1-5(10)2-4-6/h1-4,7,10H

Upstream product

• 103-16-2 4-Benzyloxyphenol 
• 88798-08-7 1-(benzyloxy)-4-(difluoromethoxy)benzene 

Downstream Products

• 885266-93-3 2-bromo-1,4-bis(difluoromethoxy)benzene 
• 1345731-62-5 (3R,5S)-4-(4-chlorobenzoyl)-7-(difluoromethoxy)-3,5-dimethyl-2,3,4,5-tetrahydro-1,4-benzoxazepine 
• 1345731-94-3 tert-butyl {(R)-2-[2-bromo-4-(difluoromethoxy)phenoxy]-1-methylethyl}carbamate 
• 88798-12-3 2-bromo-4-(difluoromethoxy)phenol 
• 1126631-64-8 pyrimidine-5-carboxylic acid (1-{1-[4-(4-difluoromethoxy-phenoxy)-phenyl]-ethylcarbamoyl}-cyclopropyl)-amide 
• 1126632-93-6 1-[4-(4-difluoromethoxy-phenoxy)-phenyl]-ethylamine 
• 1126633-17-7 1-[4-(4-difluoromethoxy-phenoxy)-phenyl]-ethanone-oxime 
• 1126633-16-6 1-[4-(4-difluoromethoxy-phenoxy)-phenyl]-ethanone 
• 1134197-98-0 4-(difluoromethoxy)-2-nitrophenol 
• 88797-83-5 O-ethyl S-propyl O-(4-difluoromethoxyphenyl)monothiophosphate 

Relevant articles and documents

TETRAZOLE-SUBSTITUTED PYRAZOLOPYRIMIDINE INHIBITORS OF JAK KINASES AND USES THEREOF

Compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined herein, and salts thereof, that are useful as JAK kinase inhibitors are described herein. Also provided are pharmac

THERAPEUTIC COMPOUNDS AND COMPOSITIONS, AND METHODS OF USE THEREOF

Compounds and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.

Diethers of m- or p-hydroxyphenol

Diethers of m- or p-hydroxyphenol, as well as the monoethers, are prepared by reacting m- or p-tert.-butoxyphenol of the formula II STR1 with a halogen compound in the presence of a hydroxide, carbonate and/or bicarbonate of an alkali metal or alkaline ea