88798-12-3Relevant academic research and scientific papers
TETRAZOLE-SUBSTITUTED PYRAZOLOPYRIMIDINE INHIBITORS OF JAK KINASES AND USES THEREOF
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, (2021/01/22)
Compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined herein, and salts thereof, that are useful as JAK kinase inhibitors are described herein. Also provided are pharmac
PYRAZOLOPYRIMIDINE COMPOUNDS AS JAK INHIBITORS
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, (2019/08/20)
Compounds and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.
THERAPEUTIC COMPOUNDS AND COMPOSITIONS, AND METHODS OF USE THEREOF
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, (2018/12/04)
Compounds and salts thereof that are useful as JAK kinse inhibitors are described herein. Also provided are pharmaceutical compositions that include such a JAK inhibitor and a pharmaceutically acceptable carrier, adjuvant or vehicle, and methods of treating or lessening the severity of a disease or condition responsive to the inhibition of a Janus kinase activity in a patient.
Discovery of potent selective orally active benzoxazepine-based orexin-2 receptor antagonists
Fujimoto, Tatsuhiko,Kunitomo, Jun,Tomata, Yoshihide,Marui, Shogo,Nishiyama, Keiji,Nakashima, Masato,Yoshikubo, Shin-Ichi,Hirai, Keisuke,Hirozane, Mariko
supporting information; experimental part, p. 6414 - 6416 (2011/11/29)
During our efforts to identify a series of potent, selective, orally active human Orexin-2 Receptor (OX2R) antagonists, we elucidated structure-activity relationship (SAR) on the 7-position of a benzoxazepine scaffold by utilizing Hammett rp and Hansch-Fu
