87797-64-6

Basic information

• Product Name: 6-methyl-2,4-di-(p-tolyl)quinoline
• Synonyms: 6-methyl-2,4-di-(p-tolyl)quinoline
• CAS NO: 87797-64-6
• Molecular Weight: 323.437
• Mol File: 87797-64-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 6-methyl-2,4-di-(p-tolyl)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-methyl-2,4-di-(p-tolyl)quinoline(87797-64-6)
• EPA Substance Registry System: 6-methyl-2,4-di-(p-tolyl)quinoline(87797-64-6)

Safety Data

• Hazardous Substances Data: 87797-64-6(Hazardous Substances Data)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 106-49-0 p-toluidine 
• 13677-51-5 1,3-bis(4-methylphenyl)prop-2-en-1-ol 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 623-11-0 1-methyl-4-nitrosobenzene 
• 1228050-59-6 C₁₇H₁₈ 
• 699-02-5 4-Methylphenethyl alcohol 
• 16979-20-7 N-(4-methylbenzylidene)-4-methylaniline 
• 87797-58-8 1,4,6-Tri-p-tolyl-1H-pyrimidin-2-one 

Relevant articles and documents

Synthesis of 2,4-Diarylquinoline Derivatives via Chloranil-Promoted Oxidative Annulation and One-Pot Reaction

An oxidative annulation for the synthesis of 2,4-diarylquinolines from o -allylanilines is disclosed that uses recyclable reagent Chloranil as the oxidant. The corresponding products are obtained in moderate to excellent yields. Furthermore, a one-pot access to 2,4-di aryl quinolines from easily available anilines and 1,3-diarylpropenes is described as a highly atom-efficient protocol that involves oxidative coupling, rearrangement, and oxidative annulation.

Synthesis method of 2, 4-diarylquinoline compound

The invention relates to a synthesis method of a 2, 4-diarylquinoline compound (II), which comprises the following steps: mixing a compound represented by a formula (I), an oxidizing agent and an organic solvent, heating to 60-80 DEG C, reacting for 1-2 hours, and carrying out after-treatment on the reaction solution to obtain a product (II). According to the synthesis method, a metal and other additives are not needed, operation is easy, raw materials are easy to obtain, and conditions are mild.

Synthesis of polysubstituted quinolines via transition-metal-free oxidative cycloisomerization of o -cinnamylanilines

An efficient synthesis of 2-aryl 4-substituted quinolines from stable and readily available o-cinnamylanilines, prepared from anilines and cinnamylalcohols, has been developed. The reaction occurred via a regioselective 6-endo-trig intramolecular oxidative cyclization using KOtBu as a mediator and DMSO as an oxidant at rt. The reaction showed a broad substrate scope with good to excellent yields.