878049-71-9Relevant academic research and scientific papers
High pressure-assisted low-loading asymmetric organocatalytic conjugate addition of nitroalkanes to chalcones
Cholewiak, Agnieszka,Adamczyk, Kamil,Kopyt, Micha?,Kasztelan, Adrian,Kwiatkowski, Piotr
, p. 4365 - 4371 (2018/06/22)
The application of high pressure (up to 9 kbar) allows for relatively fast (1-5 h) and highly enantioselective 1,4-addition of nitromethane and 2-nitropropane to chalcones at room temperature with substantial reduction of catalyst loading (0.2-1 mol% of cinchona alkaloid-based thioureas and squaramides). Various γ-nitroketones were obtained at 9 kbar with high yield and enantioselectivity (up to 98%), whereas in control experiments at atmospheric pressure usually only a small amount (10%) of products were formed after 20 h.
Enantioselective Michael addition of aromatic ketones to nitroolefins catalyzed by bifunctional thioureas and mechanistic insight
Li, Bai-Lin,Wang, Yi-Feng,Luo, Shu-Ping,Zhong, Ai-Guo,Li, Zhao-Bo,Du, Xiao-Hua,Xu, Dan-Qian
experimental part, p. 656 - 662 (2010/03/30)
A highly enantioselective Michael reaction of aromatic ketones with nitroolefins was accomplished in the presence of a chiral bifunctional primary amine-thiourea catalyst and 4-nitrobenzoic acid as the co-catalyst; the corresponding adducts were obtained
