878049-72-0Relevant academic research and scientific papers
Synthesis of a New N-Diaminophosphoryl-N'-[(2S)-2-pyrrolidinylmethyl]thiourea as a Chiral Organocatalyst for the Stereoselective Michael Addition of Cyclohexanone to Nitrostyrenes and Chalcones – Application in Cascade Processes for the Synthesis of Polyc
Cruz-Hernández, Carlos,Martínez-Martínez, Eduardo,Hernández-González, Perla E.,Juaristi, Eusebio
supporting information, p. 6890 - 6900 (2018/11/23)
A highly diastereoselective and enantioselective Michael addition of enolizable ketones such as cyclohexanone and acetophenone to a variety of substituted trans-?-nitrostyrenes and chalcones was catalyzed by a novel chiral and unsymmetrical thiourea as or
High pressure-assisted low-loading asymmetric organocatalytic conjugate addition of nitroalkanes to chalcones
Cholewiak, Agnieszka,Adamczyk, Kamil,Kopyt, Micha?,Kasztelan, Adrian,Kwiatkowski, Piotr
supporting information, p. 4365 - 4371 (2018/06/22)
The application of high pressure (up to 9 kbar) allows for relatively fast (1-5 h) and highly enantioselective 1,4-addition of nitromethane and 2-nitropropane to chalcones at room temperature with substantial reduction of catalyst loading (0.2-1 mol% of cinchona alkaloid-based thioureas and squaramides). Various γ-nitroketones were obtained at 9 kbar with high yield and enantioselectivity (up to 98%), whereas in control experiments at atmospheric pressure usually only a small amount (10%) of products were formed after 20 h.
Enantioselective addition of aryl ketones and acetone to nitroalkenes organocatalyzed by carbamate-monoprotected cyclohexa-1,2-diamines
Flores-Ferrndiz, Jess,Stiven, Alexander,Sotorros, Lia,Gmez-Bengoa, Enrique,Chinchilla, Rafael
, p. 970 - 979 (2015/09/01)
Enantiomerically pure carbamate-monoprotected trans-cyclohexane-1,2-diamines are used as chiral organocatalysts for the addition of aryl ketones and acetone to nitroalkenes to give enantioenriched β-substituted γ-nitroketones. The reaction was performed i
Asymmetric michael addition of aromatic ketones to nitroolefins catalyzed by simple chiral bifunctional primary amine-thioureas
Wang, Liangliang,Xu, Xiaoying,Huang, Jun,Peng, Lin,Huang, Qingchun,Wang, Lixin
experimental part, p. 367 - 372 (2011/03/23)
Simple chiral primary amine-thiourea catalysts derived from chiral 1,2-diphenylethylenediamine were found to catalyze direct Michael addition of aromatic ketones to nitroolefins with good enantioselectives (up to 86% ee) and excellent yields (up to 97%) f
Organocatalyzed highly stereoselective Michael addition of ketones to alkylidene malonates and nitroolefins using chiral primary-secondary diamine catalysts based on bispidine
Liu, Jie,Yang, Zhigang,Liu, Xiaohua,Wang, Zhen,Liu, Yanling,Bai, Sha,Lin, Lili,Feng, Xiaoming
supporting information; experimental part, p. 4120 - 4127 (2009/12/06)
Organocatalysts containing primary-secondary diamines based on bispidine have been developed to catalyze the asymmetric Michael addition of ketones to alkylidene malonates and nitroalkenes. The corresponding products were obtained in high yields (up to 99
