878197-93-4

Upstream product

• 109-01-3 1-methyl-piperazine 
• 878197-92-3 (5-fluoroimidazo[1,2-a]pyridin-2-yl)methanol 

Downstream Products

• 878197-72-9 5-(4-methyl-1-piperazinyl)imidazo[1,2-a]pyridine-2-carbaldehyde 

Relevant academic research and scientific papers

Kilogram-scale synthesis of the CXCR4 antagonist GSK812397

An improved, scalable synthesis of the CXCR4 antagonist GSK812397 is described. This new route was recently scaled up in 50 L fixed equipment to afford 1.2 kg of drug substance in five steps with an overall yield of 20% and >99% chemical and enantiomeric

CHEMICAL COMPOUNDS

The present invention provides compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind to chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 of a

CHEMICAL COMPOUNDS

The present invention provides compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind to chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 of a

CHEMICAL COMPOUNDS

There is provided novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind specifically to the chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as C

CHEMCIAL COMPOUNDS

The present invention provides novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind specifically to the chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 and/or CCR5 of a target cell.

CHEMICAL COMPOUNDS

The present invention provides novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind specifically to the chemokine receptor, and which affect the binding of the natural ligand or chemokine to a recep