87840-72-0Relevant articles and documents
TRIAZINONE COMPOUNDS
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Paragraph 1263; 1264, (2014/08/06)
The invention provides a compound of Formula (I) pharmaceutically acceptable salts, pro-drugs, biologically active metabolites, stereoisomers and isomers thereof wherein the variable are defined herein. The compounds of the invention are useful for treati
Bimetallic catalysis involving dipalladium(I) and diruthenium(I) complexes
Das, Raj K.,Saha, Biswajit,Rahaman, S. M. Wahidur,Bera, Jitendra K.
scheme or table, p. 14459 - 14468 (2011/03/19)
Dipalladium(I) and diruthenium(I) compounds bridged by two [{(5,7-dimethyl-1,8-naphthyridin-2-yl)amino}carbonyl]ferrocene (L) ligands have been synthesized. The X-ray structures of [Pd2L2][BF 4]2 (1) and [Ru2L2(CO) 4][BF4]2 (2) reveal dinuclear structures with short metal-metal distances. In both of these structures, naphthyridine bridges the dimetal unit, and the site trans to the metal-metal bond is occupied by weakly coordinating oxygen from the amido fragment. The catalytic utilities of these bimetallic compounds are evaluated. Compound 1 is an excellent catalyst for phosphine-free, Suzuki cross-coupling reactions of aryl bromides with arylboronic acids and provides high yields in short reaction times. Compound 1 is also found to be catalytically active for aryl chlorides, although the corresponding yields are lower. A bimetallic mechanism is proposed, which involves the oxidative addition of aryl bromide across the Pdi￡ Pd bond and the bimetallic reductive elimination of the product. Compound 1 is also an efficient catalyst for the Heck cross-coupling of aryl bromides with styrenes. The mechanism for aldehyde olefination with ethyl diazoacetate (EDA) and PPh3, catalyzed by 2, has been fully elucidated. It is demonstrated that 2 catalyzes the formation of phosphorane utilizing EDA and PPh3, which subsequently reacts with aldehyde to produce a new olefin and phosphine oxide. The efficacy of bimetallic complexes in catalytic organic transformations is illustrated in this work. Good couple: Metal-metal singly bonded [PdIi￡PdI] and [RuIi￡RuI] complexes exhibit bimetallic synergy in the catalytic Ci￡C bond-coupling and aldehyde-olefination reactions, respectively (see figure). Copyright
Osmium-catalyzed olefin dihydroxylation and aminohydroxylation in the second catalytic cycle
Wu, Peng,Hilgraf, Robert,Fokin, Valery V.
, p. 1079 - 1085 (2007/10/03)
Two catalytic cycles operate in the osmium-catalyzed olefin dihydroxylation and aminohydroxylation. Slow hydrolysis of the Os(VI) monoglycolate (or monoazaglycolate in aminohydroxylation) intermediate often results in the addition of another molecule of o
