878760-52-2Relevant academic research and scientific papers
Phosphomolybdic acid promoted Kabachnik-Fields reaction: An efficient one-pot synthesis of α-aminophosphonates from 2-cyclopropylpyrimidine-4- carbaldehyde
Reddy, Pogula Sreekanth,Reddy, Peddiahgari Vasu Govardhana,Reddy, Sura Mallikarjun
, p. 3336 - 3339 (2014/06/09)
2-Cyclopropylpyrimidin-4-yl-aryl/benzothiazole derived α- aminophosphonates were synthesized in a simple and efficient method from a three-component condensation reaction of 2-cyclopropylpyrimidin-4-carbaldehyde, various anilines/benzothiazole amines, and different phosphites by using 0.5 mol % of phosphomolybdic acid (PMA, H3PMo12O40) in dichloromethane at room temperature in good to excellent yields with short reaction times.
PYRIMIDINYLPYRAZOLES AS TGF-BETA INHIBITORS
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Page/Page column 35, (2010/10/20)
The invention is based on the discovery that compounds of formula (I) possess high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. The invention feat
