914348-07-5

Basic information

• Product Name: 2-Cyclopropyl-4-dimethoxymethyl-pyrimidine
• Synonyms: 2-Cyclopropyl-4-dimethoxymethyl-pyrimidine
• CAS NO: 914348-07-5
• Molecular Formula: C10H14N2O2
• Molecular Weight: 194.23036
• Mol File: 914348-07-5.mol

Chemical Properties

• Boiling Point: 254.5±25.0 °C(Predicted)
• Appearance: /
• Density: 1.165±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.60±0.31(Predicted)
• CAS DataBase Reference: 2-Cyclopropyl-4-dimethoxymethyl-pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclopropyl-4-dimethoxymethyl-pyrimidine(914348-07-5)
• EPA Substance Registry System: 2-Cyclopropyl-4-dimethoxymethyl-pyrimidine(914348-07-5)

Safety Data

• Hazardous Substances Data: 914348-07-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Cyclopropyl-4-dimethoxymethyl-pyrimidine is used as an anti-cancer agent for its potential to target and treat various types of cancer. Its specific mechanism of action and the cancers it targets are yet to be fully elucidated, but its potential in this area is significant.
2-Cyclopropyl-4-dimethoxymethyl-pyrimidine is also used as an anti-inflammatory agent, leveraging its properties to reduce inflammation and alleviate symptoms associated with inflammatory conditions.
Furthermore, it is used as an anti-microbial agent, indicating its potential to combat microbial infections, including bacteria and possibly other microorganisms, contributing to its broad-spectrum utility in medicine.
Additionally, 2-Cyclopropyl-4-dimethoxymethyl-pyrimidine serves as a building block in the synthesis of more complex pharmaceutical compounds, highlighting its versatility and importance in the development of new drugs with improved efficacy and safety profiles. The dimethoxymethyl group attached to the pyrimidine ring not only provides stability but also enhances the compound's overall pharmacological properties, making it a valuable ingredient in drug discovery and development processes.

Upstream product

• 67751-23-9 (E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one 
• 57297-29-7 cyclopropylcarboxamidine hydrochloride 

Downstream Products

• 878760-52-2 diphenyl (2-cyclopropylpyrimidin-4-yl)(phenylamino)methylphosphonate 
• 1610793-24-2 diphenyl (4-chlorophenylamino)(2-cyclopropylpyrimidin-4-yl)methylphosphonate 
• 1610793-25-3 diphenyl (4-bromophenylamino)(2-cyclopropylpyrimidin-4-yl)methylphosphonate 
• 1610793-26-4 diphenyl (2-cyclopropylpyrimidin-4-yl)(p-tolylamino)methylphosphonate 
• 1610793-27-5 diphenyl (benzo[d]thiazol-5-ylamino)(2-cyclopropylpyrimidin-4-yl)methylphosphonate 
• 1610793-28-6 diphenyl (benzo[d]thiazol-6-ylamino)(2-cyclopropylpyrimidin-4-yl)methylphosphonate 
• 1610793-30-0 diethyl (4-chlorophenylamino)(2-cyclopropylpyrimidin-4-yl)methylphosphonate 
• 1610793-31-1 diethyl (2-cyclopropylpyrimidin-4-yl)(p-tolylamino)methylphosphonate 
• 948549-81-3 2-cyclopropyl pyrimidine 4-carbaldehyde 

Relevant articles and documents

NEW THIENOPYRIMIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R12, X, A and n are as defined in the description.

Phosphomolybdic acid promoted Kabachnik-Fields reaction: An efficient one-pot synthesis of α-aminophosphonates from 2-cyclopropylpyrimidine-4- carbaldehyde

2-Cyclopropylpyrimidin-4-yl-aryl/benzothiazole derived α- aminophosphonates were synthesized in a simple and efficient method from a three-component condensation reaction of 2-cyclopropylpyrimidin-4-carbaldehyde, various anilines/benzothiazole amines, and different phosphites by using 0.5 mol % of phosphomolybdic acid (PMA, H3PMo12O40) in dichloromethane at room temperature in good to excellent yields with short reaction times.

PYRIMIDINYLPYRAZOLES AS TGF-BETA INHIBITORS

The invention is based on the discovery that compounds of formula (I) possess high affinity for Alk 5 and/or Alk 4, and can be useful as antagonists thereof for preventing and/or treating numerous diseases, including fibrotic disorders. The invention feat