87887-39-6Relevant academic research and scientific papers
Percutaneous absorption of cyclizine and its alkyl analogues
Monene, L. Mishack,Goosen, Colleen,Breytenbach, Jaco C.,Hadgraft, Jonathan,Du Plessis, Jeanetta
, p. 239 - 244 (2007/10/03)
Cyclizine (I) alkyl analogues (II-IV) were synthesized and their skin permeation parameters evaluated in vitro. It was hoped that these compounds would possess physicochemical properties more favourable for percutaneous delivery than (I). The identificati
A Study of the Phase-transfer Alkoxycarbonylation of Secondary Alkyl Amines. Application of a Factorial Design
Gomez-Parra, Vicente,Sanchez, Felix,Torres, Tomas
, p. 695 - 698 (2007/10/02)
A 24 factorial design has been applied to the study of the competitive alkylation versus alkoxycarbonylation of secondary alkyl amines under phase-transfer conditions.The relative influence of the experimental variables and their interactions in the course of the reaction have been rationalized.The optimal conditions to obtain high carbamate yields have been established and experimentally corroborated.
