879097-59-3

Upstream product

• 144690-33-5 ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({2'-[1-(triphenylmethyl)-1H-1,2,3,4-tetrazol-5-yl]-[1,1'-biphenyl]-4-yl}methyl)-1H-imidazole-5-carboxylate 
• 124750-51-2 N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole 
• 144689-93-0 ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylate 

Downstream Products

• 144690-92-6 trityl olmesartan medoxomil 
• 144689-63-4 olmesartan medoxomil 

Relevant academic research and scientific papers

Preparation and purification method for triphenyl methyl olmesartan compound (I)

The present invention provides a preparation and purification method for triphenyl methyl olmesartan. The method comprises the following steps: forming a triphenyl methyl olmesartan carboxylate reaction liquid by using ethyl 4-(2-hydroxy-2-propanyl)-2-pro

A olmesartan medoxomil and its preparation method (by machine translation)

The invention discloses a olmesartan medoxomil and its preparation method, the present invention discloses a olmesartan medoxomil, its chemical structure is: The present invention novel method for preparation method, comprises the following steps: (1) preparing AMST - 3 C45 H44 N6 O3 ; (2) preparing C43 H39 N6 NaO3 AMST - 4; (3) preparing C48 H44 N6 O6 AMST - 6; (4) preparing olmesartan sha tanzhi thick; (5) to make the C29 H30 N6 O6 Olmesartan medoxomil. The invention separation effect is good, relatively low viscosity system, split-phase required time is short, the time is saved but also reduces energy consumption. Filtering and separating the high recovery rate, the product quality is high, the running cost is low; process without the need to add chemical, solvent solvent, not into the secondary pollution material; equipment and automatic operation, good stability, easy to realize industrial demand. (by machine translation)

A process for the preparation of olmesartan

The invention relates to a method for preparing a medicine olmesartan medoxomil for treating hypertension, belongs to the field of medicines, and provides a method for preparing the olmesartan medoxomil with low material cost and mild reaction condition. The method comprises the following steps of: feeding two initial raw materials ( a compound 1 and a compound 2) according to a mole ratio of 1:1 during the process; adding the polyethylene glycol/N,N-dimethylacetamide composite catalyst to be completely reacted with the two initial raw materials so as to avoid a necessary impurity control process caused by excessive raw materials during classic reaction; and removing triphenylmethyl from a methanol/organic solvent mixed system to avoid participation of acid. Based on the improvement, the operation is greatly simplified, the cost is reduced, and the industrial production is facilitated.

Improved synthesis process of olmesartan medoxomil derivatives

The present invention relates to an improved olmesartan medoxomil derivative preparation method. More specifically, the olmesartan medoxomil derivative preparation method includes the steps of: initiating a coupling reaction between imidazole compounds and biphenyl methyl halide compounds; initiating a de-esterification reaction of the products of the coupling reaction; and initiating a condensation reaction between the de-esterified products with dioxolen derivatives. The present invention can optimize the reaction conditions of the coupling and de-esterification reactions to minimixe the content of the conventionally produced byproducts and residual solvent to significantly increase the yield and purity of the target products. The final olmesartan medoxomil derivatives obtained by using the method has the residual solvent content less than or equal to 500 ppm, thereby being lowered to 1/10 or less of the ICH guidelines.