879220-59-4

Upstream product

• 667-27-6 Ethyl bromodifluoroacetate 
• 122-78-1 phenylacetaldehyde 
• 91298-74-7 (S)-2-methoxy-1-phenylethylamine 

Downstream Products

• 879220-64-1 (6S)-6-benzyl-3,6-dihydro-5-fluoro-1H-pyridin-2-one 
• 879220-62-9 (6S)-6-benzyl-5,5-difluoro-5,6-dihydropyridin-2(1H)-one 
• 879220-82-3 tert-butyl (5S,3Z)-5-[N-(tert-butoxycarbonyl)amino]-4-fluoro-6-phenylhex-3-enoate 
• 879220-61-8 tert-butyl (5S,2Z)-5-[N-(tert-butoxycarbonyl)amino]-4,4-difluoro-6-phenylhex-2-enoate 
• 879220-81-2 tert-butyl (5S,2E)-5-[N-(tert-butoxycarbonyl)amino]-4,4-difluoro-6-phenylhex-2-enoate 
• 879220-87-8 5-tert-butoxycarbonylamino-4,4-difluoro-6-phenyl-hexanoic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of fluoroalkene dipeptide isosteres by an intramolecular redox reaction utilizing N-Heteorocyclic carbenes (NHCs)

(Z)-Fluoroalkene dipeptide isosteres (FADIs 16) have served as potential dipeptide mimetics possessing the substitution of fluoroalkenes for parent peptide bonds. Previously, we synthesized FADIs by reduction of γ,γ-difluoro-α,β-enoates with organocoppers

Unequivocal synthesis of (Z)-alkene and (E)-fluoroalkene dipeptide isosteres to probe structural requirements of the peptide transporter PEPT1

Described is a novel synthetic route for dipeptide isosteres containing (Z)-alkene and (E)-fluoroalkene units as cis-amide bond equivalents via organocopper-mediated reduction of γ-acetoxy- or γ,γ-difluoro- α,β-unsaturated-δ-lactams. The synthesized isost