879220-59-4Relevant academic research and scientific papers
Synthesis of fluoroalkene dipeptide isosteres by an intramolecular redox reaction utilizing N-Heteorocyclic carbenes (NHCs)
Yamaki, Yoko,Shigenaga, Akira,Tomita, Kenji,Narumi, Tetsuo,Fujii, Nobutaka,Otaka, Akira
body text, p. 3272 - 3277 (2009/09/08)
(Z)-Fluoroalkene dipeptide isosteres (FADIs 16) have served as potential dipeptide mimetics possessing the substitution of fluoroalkenes for parent peptide bonds. Previously, we synthesized FADIs by reduction of γ,γ-difluoro-α,β-enoates with organocoppers
Unequivocal synthesis of (Z)-alkene and (E)-fluoroalkene dipeptide isosteres to probe structural requirements of the peptide transporter PEPT1
Niida, Ayumu,Tomita, Kenji,Mizumoto, Makiko,Tanigaki, Hiroaki,Terada, Tomohiro,Oishi, Shinya,Otaka, Akira,Inui, Ken-Ichi,Fujii, Nobutaka
, p. 613 - 616 (2007/10/03)
Described is a novel synthetic route for dipeptide isosteres containing (Z)-alkene and (E)-fluoroalkene units as cis-amide bond equivalents via organocopper-mediated reduction of γ-acetoxy- or γ,γ-difluoro- α,β-unsaturated-δ-lactams. The synthesized isost
