879220-81-2

Basic information

• Product Name: 2-Hexenoic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-4,4-difluoro-6-phenyl-, 1,1-dimethylethyl ester, (2E,5S)-
• CAS NO: 879220-81-2
• Molecular Formula: C21H29F2NO4
• Molecular Weight: 397.462
• Mol File: 879220-81-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Hexenoic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-4,4-difluoro-6-phenyl-, 1,1-dimethylethyl ester, (2E,5S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hexenoic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-4,4-difluoro-6-phenyl-, 1,1-dimethylethyl ester, (2E,5S)-(879220-81-2)
• EPA Substance Registry System: 2-Hexenoic acid, 5-[[(1,1-dimethylethoxy)carbonyl]amino]-4,4-difluoro-6-phenyl-, 1,1-dimethylethyl ester, (2E,5S)-(879220-81-2)

Safety Data

• Hazardous Substances Data: 879220-81-2(Hazardous Substances Data)

Upstream product

• 122-78-1 phenylacetaldehyde 
• 24424-99-5 di-tert-butyl dicarbonate 
• 879220-59-4 ethyl (3S)-2,2-difluoro-3-{N-[(1S)-(2-methoxy-1-phenylethyl)]amino}-4-phenylbutanoate 
• 879220-60-7 ethyl (3S)-3-[N-(tert-butoxycarbonyl)amino]-2,2-difluoro-4-phenylbutanoate 
• 27784-76-5 tert-butyl diethylphosphonoacetate 

Downstream Products

• 879220-87-8 5-tert-butoxycarbonylamino-4,4-difluoro-6-phenyl-hexanoic acid tert-butyl ester 
• 879220-82-3 tert-butyl (5S,3Z)-5-[N-(tert-butoxycarbonyl)amino]-4-fluoro-6-phenylhex-3-enoate 

Relevant articles and documents

Unequivocal synthesis of (Z)-alkene and (E)-fluoroalkene dipeptide isosteres to probe structural requirements of the peptide transporter PEPT1

Described is a novel synthetic route for dipeptide isosteres containing (Z)-alkene and (E)-fluoroalkene units as cis-amide bond equivalents via organocopper-mediated reduction of γ-acetoxy- or γ,γ-difluoro- α,β-unsaturated-δ-lactams. The synthesized isost