879324-64-8

Basic information

• Product Name: 2-(4-FLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID
• Synonyms: 2-(4-FLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID;Cyclopropanecarboxylic acid, 2-(4-fluorophenyl)-;2-(4-fluorophenyl)cyclopropane-1-carboxylic acid;2-(4-Fluorophenyl)Cyclopropanecarboxylic Acid(WXC00568)
• CAS NO: 879324-64-8
• Molecular Formula: C10H9FO2
• Molecular Weight: 180.18
• Mol File: 879324-64-8.mol
• Article Data: 26

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-(4-FLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID(879324-64-8)
• EPA Substance Registry System: 2-(4-FLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID(879324-64-8)

Safety Data

• Hazardous Substances Data: 879324-64-8(Hazardous Substances Data)

Usage

General Description

2-(4-Fluorophenyl)cyclopropanecarboxylic acid is a synthetic compound with a cyclopropane ring and a carboxylic acid functional group. It is also known by the chemical name "4-Fluorophenylcyclopropanecarboxylic acid." 2-(4-FLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID is not commonly found in nature and must be synthesized in a laboratory setting. It has potential applications in pharmaceutical research and drug development due to its unique structural features and ability to interact with biological systems. 2-(4-FLUOROPHENYL)CYCLOPROPANECARBOXYLIC ACID may also have uses in the field of organic chemistry as a building block for other chemical compounds. However, further research is needed to fully understand its potential uses and properties.

Upstream product

• 893751-08-1 trans-methyl 2-(4-fluorophenyl)cyclopropanecarboxylate 
• 623-73-4 diazoacetic acid ethyl ester 
• 405-99-2 para-fluorostyrene 
• 301861-15-4 (+/-)-trans-2-(4-fluorophenyl)cyclopropanecarbonitrile 
• 301861-15-4 (+/-)-cis-2-(4-fluorophenyl)cyclopropanecarbonitrile 
• 70461-58-4 trans-2-(4-fluorophenyl)cyclopropane carboxylic acid ethyl ester 
• 352-34-1 4-fluoro-1-iodobenzene 
• 243665-10-3 (E)-3-(4-fluorophenyl)-N-methoxy-N-methylacrylamide 
• 459-57-4 4-fluorobenzaldehyde 
• 75-47-8 iodoform 
• 459-32-5 (E)-4-fluorocinnamic acid 
• 214360-58-4 2-(4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1759-53-1 cyclopropanecarboxylic acid 
• 893751-08-1 methyl 2-(4-fluorophenyl)cyclopropane-1-carboxylate 

Downstream Products

• 161711-27-9 (1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid 
• 1414775-42-0 (1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid [(R)-cyclopropyl-(3-ethanesulfonylphenyl)methyl](6-trifluoromethylpyridin-3-ylmethyl)amide 
• 1414775-44-2 (1R,2R)-2-(4-fluorophenyl)cyclopropanecarboxylic acid [(S)-cyclopropyl-(3-ethanesulfonylphenyl)methyl](6-trifluoromethylpyridin-3-ylmethyl)amide 
• 1314323-96-0 (1R,2S)-tert-butyl 2-(4-fluorophenyl)cyclopropylcarbamate 
• 113516-71-5 (1R,2S)-2-(4-fluorophenyl)cyclopropan-1-amine 
• 515179-19-8 (+)-(1S,2S)-2-(4-fluorophenyl)cyclopropanecarboxylic acid 
• 1609030-98-9 2-(4-fluorophenyl)-N-(2-(2-methyl-1H-indol-1-yl)ethyl)cyclopropane-1-carboxamide 

Relevant articles and documents

PD(II)-CATALYZED ENANTIOSELECTIVE C-H ARYLATION OF FREE CARBOXYLIC ACIDS

The invention includes procedures for stereoselective β-arylation of carboxylic acids having a β-carbon atom. For example, stereoselective arylation procedures include the following reactions: (I)

Co(II)-salen catalyzed stereoselective cyclopropanation of fluorinated styrenes

Three cis-selective Co(II)-salen complexes have been developed for the asymmetric cyclopropanation of para-fluorinated styrenes with ethyl diazoacetate. Increasing the steric reach of the C2-symmetric ligand side chains improved the enantiomeric ratio of the reaction from 28:1 to 66:1. The methodology was exemplified by the gram-scale synthesis of a lead compound for the treatment of castration-resistant prostate cancer (CRPC), as well as a structurally related analog.

Synthesis and in vitro evaluation of novel N-cycloalkylcarbamates as potential cholinesterase inhibitors

Abstract: This present paper describes the preparation and characterization of a series of O-substituted N-cycloalkylcarbamate derivatives. These compounds were tested as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). All studied carbamates exhibited moderate inhibitory activity of both cholinesterases with values of IC50 in the range of 36.1–78.6?μM for AChE and 9.8–215.4?μM for BChE, respectively. These values are comparable with those values of inhibition obtained with the established drug rivastigmine. The cytotoxicity of all carbamates was evaluated using standard in vitro test with Jurkat cells. Many of the studied carbamates can be considered as promising compounds for potential medicinal applications with regard to their inhibitory activity as well as negligible cytotoxicity.