87935-91-9Relevant academic research and scientific papers
Structure of the epigenetic oncogene MMSET and inhibition by N-alkyl sinefungin derivatives
Tisi, Dominic,Chiarparin, Elisabetta,Tamanini, Emiliano,Pathuri, Puja,Coyle, Joseph E.,Hold, Adam,Holding, Finn P.,Amin, Nader,Martin, Agnes C. L.,Rich, Sharna J.,Berdini, Valerio,Yon, Jeff,Acklam, Paul,Burke, Rosemary,Drouin, Ludovic,Harmer, Jenny E.,Jeganathan, Fiona,Van Montfort, Rob L. M.,Newbatt, Yvette,Tortorici, Marcello,Westlake, Maura,Wood, Amy,Hoelder, Swen,Heightman, Tom D.
, p. 3093 - 3105 (2016)
The members of the NSD subfamily of lysine methyl transferases are compelling oncology targets due to the recent characterization of gain-of-function mutations and translocations in several hematological cancers. To date, these proteins have proven intrac
