87949-12-0

Basic information

• Product Name: 1-(4-FLUORO-PHENYL)-1H-PYRAZOL-3-AMINE
• Synonyms: 1-(4-FLUORO-PHENYL)-1H-PYRAZOL-3-AMINE
• CAS NO: 87949-12-0
• Molecular Formula: C₉H₈FN₃
• Molecular Weight: 177.1783232
• Mol File: 87949-12-0.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-FLUORO-PHENYL)-1H-PYRAZOL-3-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUORO-PHENYL)-1H-PYRAZOL-3-AMINE(87949-12-0)
• EPA Substance Registry System: 1-(4-FLUORO-PHENYL)-1H-PYRAZOL-3-AMINE(87949-12-0)

Safety Data

• Hazardous Substances Data: 87949-12-0(Hazardous Substances Data)

Usage

Chemical structure

A pyrazole derivative with a fluorine-substituted phenyl ring and an amino group.

Potential applications

a. Pharmaceutical research and development
b. Synthesis of various organic compounds
c. Building block in drug discovery and medicinal chemistry
d. Study of pyrazole-based compounds and their effects on biological systems

Structural properties

The presence of a fluorine atom in the phenyl ring and an amino group in the pyrazole structure contribute to its potential biological activities and reactivity in chemical reactions.

Research and industry relevance

Valuable chemical with potential applications in various fields of research and industry, including drug development and organic synthesis.

Upstream product

• 1820-80-0 3-aminopyrazole 
• 352-34-1 4-fluoro-1-iodobenzene 
• 1765-93-1 4-fluoroboronic acid 
• 61310-53-0 3-ethoxyacrylonitrile 
• 823-85-8 4-fluorophenyhydrazine hydrochloride 

Downstream Products

• 1621525-03-8 1-(4-fluorophenyl)-3-iodo-1H-pyrazole 
• 1316120-59-8 6-Methyl-3-(pyrimidin-5-ylamino)-pyridine-2-carboxylic acid [1-(4-fluoro-phenyl)-1H-pyrazol-3-yl]-amide 
• 328232-94-6 trans-N-[1-(4-fluorophenyl)-1H-pyrazol-3-yl]-3-oxo-3H-spiro[6-aza-2-benzofuran-1,1'-cyclohexane]-4'-carboxamide 
• 104164-06-9 5-Chloromethyl-1-(4-fluoro-phenyl)-1H-pyrazolo[1,5-a]pyrimidin-7-one 

Relevant articles and documents

1,3-SUBSTITUED PYRAZOLE COMPOUNDS USEFUL FOR REDUCTION OF VERY LONG CHAIN FATTY ACIC LEVELS

Disclosed are chemical entities which are compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein Formula (I) has the structure: R1a, R1b, R2, R3, R4a, R4b and Y are as defined herein. These chemical entities are useful for reduction of very long chain fatty acid levels. These chemical entities and pharmaceutically acceptable compositions comprising such chemical entities can be useful for treating various diseases, disorders and conditions, such as adrenoleukodystrophy (ALD).

Copper(I)/Copper(II)-Assisted Tandem Catalysis: The Case Study of Ullmann/Chan-Evans-Lam N1,N3-Diarylation of 3-Aminopyrazole

Unprecedented CuI/CuII-assisted tandem catalysis allowing an Ullmann/Chan-Evans-Lam sequence was achieved. This three-component, one-pot reaction triggered by a change in the oxidation state of the metal leads to the selective N1,N3-diarylation of 3-aminopyrazole. This new method should be a valuable tool for small-molecule drug discovery that requires suitable regio- and/or chemoselective strategies for the N-arylation of nitrogen-containing heterocycles. Tandem power: The first assisted tandem copper-catalyzed process, triggered by a change in the oxidation state of the metal, is developed to allow a one-pot Ullman/Chan-Evans-Lam sequence leading to the selective N1,N3-diarylation of 3-aminopyrazole.

NITROGEN-CONTAINING HETEROARYL DERIVATIVES

The invention is concerned with novel nitrogen-containing heteroaryl derivatives of formula (I) wherein R1, R2, R3, R4, R5, A1, A2, and Y are as defined in the description and in