87952-98-5 Usage
Uses
A new mineralocorticoid antagonist; has an inhibition effect on aldosterone-induced hypertension.
Check Digit Verification of cas no
The CAS Registry Mumber 87952-98-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,7,9,5 and 2 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 87952-98:
(7*8)+(6*7)+(5*9)+(4*5)+(3*2)+(2*9)+(1*8)=195
195 % 10 = 5
So 87952-98-5 is a valid CAS Registry Number.
InChI:InChI=1/C25H30O4S/c1-13(26)30-19-11-14-10-15(27)4-7-23(14,2)17-5-8-24(3)22(21(17)19)16-12-18(16)25(24)9-6-20(28)29-25/h4,7,10,16-19,21-22H,5-6,8-9,11-12H2,1-3H3/t16-,17+,18+,19-,21+,22+,23+,24+,25+/m1/s1
87952-98-5Relevant articles and documents
Aldosterone antagonists. 2. New 7α-(acetylthio)-15,16-methylene spirolactones
Nickisch,Bittler,Laurent,Losert,Casals-Stenzel,Nishino,Schillinger,Wiechert
, p. 1403 - 1409 (2007/10/02)
Some 15,16-methylene derivatives of the aldosterone antagonist spironolactone (1) were synthesized with the purpose of increasing the antialdosterone potency and reducing the endocrinological effects of this standard compound. By introduction of a 1,2-double bond and a 15β,16β-methylene ring in the spironolactone molecule both goals were achieved. In animal studies mespirenone (13) exhibited a threefold-greater antiandosterone potency and less than 10% of the antiandrogenic activity of spironolactone.