879873-91-3

Upstream product

• 879873-90-2 2-{6-[2-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)ethyl]-2,2-dimethyl[1,3]dioxan-4-yl}propionaldehyde 
• 5927-18-4 trimethyl phosphonoacetate 
• 89238-99-3 O-(4-methoxybenzyl)-trichloroacetimidate 
• 408348-31-2 (1R,2R)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane 
• 879873-88-8 4-[1-(tert-butyldimethylsilanyloxymethyl)ethyl]-6-[2-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)ethyl]-2,2-dimethyl-[1,3]dioxan 
• 879873-81-1 4-(2-[tert-butyldiphenylsilanyloxymethyl]cyclopropyl)-4-(4-methoxybenzyloxy)-2-methyl-1-butene 
• 879873-87-7 (1S,3S,5S,6S)-7-(tert-Butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-6-methyl-1-((1R,2R)-2-methyl-cyclopropyl)-heptane-3,5-diol 
• 879873-86-6 7-(tert-butyldimethylsilanyloxy)-5-hydroxy-1-(4-methoxybenzyloxy)-6-methyl-1-(2-methylcyclopropyl)heptan-3-one 
• 879873-89-9 (S)-2-{(4S,6R)-6-[(S)-2-(4-Methoxy-benzyloxy)-2-((1R,2R)-2-methyl-cyclopropyl)-ethyl]-2,2-dimethyl-[1,3]dioxan-4-yl}-propan-1-ol 
• 879873-80-0 (S)-1-[(1R,2R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-cyclopropyl]-3-methyl-but-3-en-1-ol 
• 879873-82-2 {(1R,2R)-2-[(S)-1-(4-Methoxy-benzyloxy)-3-methyl-but-3-enyl]-cyclopropyl}-methanol 
• 879873-83-3 4-(2-bromomethylcyclopropyl)-4-(4-methoxybenzyloxy)-2-methyl-1-butene 
• 879873-84-4 1-Methoxy-4-[(S)-3-methyl-1-((1R,2R)-2-methyl-cyclopropyl)-but-3-enyloxymethyl]-benzene 
• 879873-85-5 4-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)butan-2-one 

Downstream Products

• 879873-94-6 {(2S,3S,4S,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-6-[(S)-2-(4-methoxy-benzyloxy)-2-((1R,2R)-2-methyl-cyclopropyl)-ethyl]-3-methyl-tetrahydro-pyran-2-yl}-acetic acid methyl ester 
• 879873-93-5 {4-hydroxy-6-[2-(4-methoxybenzyloxy)-2-(2-methylcyclopropyl)ethyl]-3-methyltetrahydropyran-2-yl}acetic acid methyl ester 
• 879873-92-4 5,7-dihydroxy-9-(4-methoxybenzyloxy)-4-methyl-9-(2-methylcyclopropyl)non-2-enoic acid methyl ester 

Relevant academic research and scientific papers

Enantioselective total synthesis of (-)-Clavosolide A and B

Enantioselective total synthesis of (-)-clavosolide A and B was reported in full including the synthesis of proposed structure of (-)-clavosoldie A (1), revised structure of (-)-clavosoldie A (5), and revised structure of (-)-clavosoldie B (6). The relative and absolute stereochemistries of the natural products were confirmed unambiguously by comparing the optical rotation values and 1H and 13C NMR spectra of them.

Total synthesis, structural revision, and absolute configuration of (+)-clavosolide A

Enantioselective synthesis of 3, a revised structure for clavosolide A, was completed. Both 1H and 13C NMR spectra of the natural and synthetic compounds were identical, and optical rotation measurements identified the absolute confi