879880-13-4Relevant academic research and scientific papers
Modification of estrone at the 6, 16, and 17 positions: Novel potent inhibitors of 17β-hydroxysteroid dehydrogenase type 1
Allan, Gillian M.,Lawrence, Harshani R.,Cornet, Josephine,Bubert, Christian,Fischer, Delphine S.,Vicker, Nigel,Smith, Andrew,Tutill, Helena J.,Purohit, Atul,Day, Joanna M.,Mahon, Mary F.,Reed, Michael J.,Potter, Barry V. L.
, p. 1325 - 1345 (2006)
The 17β-hydroxysteroid dehydrogenases (17β-HSDs) catalyze the interconversion between the oxidized and reduced forms of androgens and estrogens at the 17 position. The 17β-HSD type 1 enzyme (17β-HSD1) catalyzes the reduction of estrone to estradiol and is
Synthesis of monomeric and dimeric steroids containing [1,2,4]triazolo[1,5-a]pyrimidines
Arenas-González, Ailed,Mendez-Delgado, Luis Antonio,Merino-Montiel, Penélope,Padrón, José M.,Montiel-Smith, Sara,Vega-Báez, José Luis,Meza- Reyes, Socorro
, p. 13 - 19 (2016/10/11)
The synthesis of several monomeric and dimeric steroidal [1,2,4]triazolo[1,5-a]pyrimidines (TPs) derived from steroids are described. These derivatives were prepared from α,β-unsaturated carbonyl compounds through a Claisen Schmidt condensation and rearrangement of the spiro moiety followed by a cycloaddition with 3-amino-1,2,4-triazole. The antiproliferative activity of compounds 7, 13–15 was tested against human cancer cells; several IG50values were below 10?μM.
Synthesis of novel 16-spiro steroids: 7-(Aryl)tetrahydro-1H-pyrrolo[1,2-c] [1,3]thiazolo estrone hybrid heterocycles
Jeyachandran, Veerappan,Vivek Kumar, Sundaravel,Ranjith Kumar, Raju
, p. 29 - 37 (2014/03/21)
The 1,3-dipolar cycloaddition of azomethine ylides generated in situ from the reaction of isatins or acenaphthylene-1,2-dione and 1,3-thiazolane-4- carboxylic acid to various exocyclic dipolarophiles synthesized from estrone afforded a library of novel C-
