879892-98-5

Basic information

• Product Name: Propanoic acid, 2,2-dimethyl-, 3-[1-(4-hydroxyphenyl)-2-phenyl-1-butenyl]phenyl ester
• CAS NO: 879892-98-5
• Molecular Formula: C27H28O3
• Molecular Weight: 400.518
• Mol File: 879892-98-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Propanoic acid, 2,2-dimethyl-, 3-[1-(4-hydroxyphenyl)-2-phenyl-1-butenyl]phenyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanoic acid, 2,2-dimethyl-, 3-[1-(4-hydroxyphenyl)-2-phenyl-1-butenyl]phenyl ester(879892-98-5)
• EPA Substance Registry System: Propanoic acid, 2,2-dimethyl-, 3-[1-(4-hydroxyphenyl)-2-phenyl-1-butenyl]phenyl ester(879892-98-5)

Safety Data

• Hazardous Substances Data: 879892-98-5(Hazardous Substances Data)

Upstream product

• 40595-34-4 (E)-trimethyl(3-phenylallyl)silane 
• 693818-54-1 4-(4-methoxyphenyl)-3-phenyl-4-(3-pivaloyloxyphenyl)but-1-ene 
• 134518-89-1 3-pivaloyloxybenzaldehyde 
• 100-66-3 methoxybenzene 
• 879892-92-9 3,5-dinitro-benzoic acid 3-{1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-phenyl-but-1-enyl}-phenyl ester 
• 879892-90-7 3,5-Dinitro-benzoic acid 3-[(E)-1-(4-hydroxy-phenyl)-2-phenyl-but-1-enyl]-phenyl ester 
• 879892-88-3 3,5-Dinitro-benzoic acid 3-[(E)-1-(4-methoxy-phenyl)-2-phenyl-but-1-enyl]-phenyl ester 
• 879892-94-1 3-{1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-phenyl-but-1-enyl}-phenol 
• 879892-86-1 3-[(E)-1-(4-Methoxy-phenyl)-2-phenyl-but-1-enyl]-phenol 
• 879892-96-3 2,2-dimethyl-propionic acid 3-{1-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-phenyl-but-1-enyl}-phenyl ester 

Downstream Products

• 82413-20-5 Droloxifene 
• 879893-00-2 2,2-Dimethyl-propionic acid 3-{(E)-1-[4-(2-dimethylamino-ethoxy)-phenyl]-2-phenyl-but-1-enyl}-phenyl ester 

Relevant articles and documents

Short-step synthesis of droloxifene via the three-component coupling reaction among aromatic aldehyde, cinnamyltrimethylsilane, and β-chlorophenetole

A short-step route for the preparation of droloxifene has been established via the novel three-component coupling reaction among 3-pivaloyloxybenzaldehyde, cinnamyltrimethylsilane, and β-chlorophenetole, the successive installation of the side-chain part, and the base-induced migration of the double bond. The present synthesis of tetra-substituted ethylene moieties is a widely applicable strategy for producing a variety of SERMs (selective estrogen receptor modulators) and SARMs (selective androgen receptor modulators), such as tamoxifen, raloxifene, and other compounds that can lead to new drugs.